Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT05268341 · ClinicalTrials.gov registry record · NA
Neuroimaging Reveals Treatment-related Changes in DLD
A NA study of Developmental Language Disorder, sponsored by University of Cincinnati.
- Recruiting
- Registry status
- NA
- Development phase
- 184
- Enrollment target
- 6
- Study locations
NCT05268341: Recruiting NA study of Developmental Language Disorder, sponsored by University of Cincinnati.
NCT05268341 is a NA study of Developmental Language Disorder that is actively recruiting participants, run by University of Cincinnati. The registered enrollment target is 184 participants, roughly in line with the 172-participant average among 17 other Developmental Language Disorder trials with a reported enrollment target. The trial reports 6 study locations across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05268341, a NA study of Developmental Language Disorder, is actively recruiting participants, sponsored by University of Cincinnati.
- RECRUITING
- Registry status
- NA
- Development phase
- 184 participants
- Enrollment target
- 6
- Study locations
Study Summary
Children with developmental language disorders (DLD, aka specific language impairment), a prevalent pediatric disorder, experience hallmark grammar deficits with life-long impacts on educational and occupational outcomes. While effective and early interventions can mitigate the impact of DLD, not enough is known about the neural basis of DLD in young children, yet is needed to inform the design of more individualized interventions. This project uses neuroimaging, along with behavioral methods, with the goal of better understanding the memory-language mechanisms that underlie grammar learning and impairment, while also considering their association to treatment-related changes in preschoolers with DLD.
Primary Outcome
Aim 1 (all TD and DLD preschoolers)- Primary: Pre/Time 1 data for functional connectivity (assessed using fMRI from the Sentence Completion Expressive Language Task- Preschool (SCELT-P)) between Regions of Interest (ROI) in the procedural learning network and in the declarative memory network
Conditions Studied
Interventions
- BEHAVIORAL My Sentence Builder
Study Locations (6)
Ohio
- New Horizon Childcare - Cincinati
- Empower Learn Create INC - Cincinnati
- Cincinnati Children's Hospital - Cincinnati
- CWFF CHild Development Center - Cincinnati
- Wesley Education Center for Children and Families - Cincinnati
- University of Cincinnati - Cincinnati
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 184 participants |
| Start Date | 2022-05-24 |
| Est. Completion | 2027-06-30 |
| Phase | NA |
What NCT05268341 shows while recruiting
NCT05268341 is an interventional study that assigns participants to a tested intervention. The registered 184 participants enrollment target is mid-sized for trials with a published cap, roughly in line with the 172-participant average among 17 other Developmental Language Disorder trials with a reported enrollment target.
The record links to 1 condition, with Developmental Language Disorder appearing as the primary indexed condition, and to 1 intervention - of which My Sentence Builder is the first listed.
NCT05268341 lists 6 locations in 1 state (Ohio).
Frequently Asked Questions
What is clinical trial NCT05268341 about?
NCT05268341 is a clinical study titled "Neuroimaging Reveals Treatment-related Changes in DLD". Children with developmental language disorders (DLD, aka specific language impairment), a prevalent pediatric disorder, experience hallmark grammar deficits with life-long impacts on educational and occupational outcomes. While effective and early interventions can mitigate the impact of DLD, not en...
What is the current status of trial NCT05268341?
This trial is currently recruiting. It is a NA study. The enrollment target is 184 participants. The study started on 2022-05-24. Estimated completion is 2027-06-30.
What conditions does trial NCT05268341 study?
This clinical trial studies the following conditions: Developmental Language Disorder.
What interventions are being tested in trial NCT05268341?
The interventions under investigation include: My Sentence Builder (BEHAVIORAL).
Who is sponsoring clinical trial NCT05268341?
This trial is sponsored by University of Cincinnati, which has 245 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05268341 being conducted?
This trial has 6 study locations across Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Developmental Language Disorder
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05268341's enrollment target sits among peer trials
184 6th of 17 higher than 12 of 17 other Developmental Language Disorder trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Developmental Language Disorder trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Contextual Word Learning in Children With Developmental Language Disorder
RECRUITING · NA
-
Emergent Bilinguals: Child Language Proficiency and Language of Treatment
RECRUITING · NA
-
The Short-term Verbal Memory Endophenotype for Developmental Language Disorder Language Disorder
RECRUITING · NA
-
A Developmental Framework For Linking Phonological And Morpho-syntactic Sequential Pattern Rules In DLD: Production
RECRUITING · NA
-
Optimizing Feedback-based Learning in Children With Developmental Language Disorder
RECRUITING · NA
-
Retrieval-based Word Learning in Developmental Language Disorder: Adaptive Retrieval Schedule
RECRUITING · NA
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT03903510 · 184 participants · NA
Virtual Reality During Pediatric Cast Removal
- NCT04020510 · 184 participants · Phase 4
Standard Injections Versus Reduced Injections for Intravesical onabotulinumtoxinA Treatment of Overactive Bladder
- NCT04135846 · 184 participants · Phase 2
Alpha-1 Blockade for Alcohol Use Disorder (AUD)
- NCT04396873 · 184 participants · Phase 1
PET Imaging of Cyclooxygenases in Neurodegenerative Brain Disease
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI