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RECRUITING Phase 2

4D-710 in Adult Patients With Cystic Fibrosis

NCT05248230 · View on ClinicalTrials.gov ↗

Study Summary

This is a Phase 1/2 multicenter, open-label, single dose trial of 4D-710 investigational gene therapy in adults with cystic fibrosis.

Conditions Studied

Interventions

  • BIOLOGICAL 4D-710

Study Locations (20)

Florida

  • University of Florida — Gainesville
  • University of Miami Hospital — Miami

Massachusetts

  • Massachusetts General Hospital — Boston
  • Boston Children's Hospital — Boston

Ohio

  • Rainbow Babies and Children's Hospital/University Hospitals Cleveland Medical Center — Cleveland
  • Nationwide Children's Hospital — Columbus

Pennsylvania

  • Penn State Health — Hershey
  • The Hospital of the University of Pennsylvania — Philadelphia

Alabama

  • University of Alabama Child Health Research Unit — Birmingham

Arizona

  • The University of Arizona — Tucson

California

  • University of California San Francisco — San Francisco

Colorado

  • National Jewish Health — Denver

Trial Details

FieldValue
Enrollment Target 30 participants
Start Date 2022-03-29
Est. Completion 2031-06
Phase Phase 2

Sponsor

4D Molecular Therapeutics

36 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05248230

The ClinicalTrials.gov registry entry for NCT05248230 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 30 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is 4D Molecular Therapeutics, which has 36 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Cystic Fibrosis Lung appearing as the primary indexed condition, and to 1 intervention — of which 4D-710 is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT05248230 reports 20 study locations spanning 16 distinct geographic areas — top geographies include Florida, Massachusetts, Ohio. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT05248230 about?

NCT05248230 is a clinical study titled "4D-710 in Adult Patients With Cystic Fibrosis". This is a Phase 1/2 multicenter, open-label, single dose trial of 4D-710 investigational gene therapy in adults with cystic fibrosis.

What is the current status of trial NCT05248230?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 30 participants. The study started on 2022-03-29. Estimated completion is 2031-06.

What conditions does trial NCT05248230 study?

This clinical trial studies the following conditions: Cystic Fibrosis Lung. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT05248230?

The interventions under investigation include: 4D-710 (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT05248230?

This trial is sponsored by 4D Molecular Therapeutics, which has 36 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT05248230 being conducted?

This trial has 20 study locations across Alabama, Arizona, California, Colorado, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial