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NCT05194098 · ClinicalTrials.gov registry record · NA
Using Electrophysiology to Index Non-invasive Brain Stimulation Effects on Reward System Functioning in Depression
A NA study of Major Depressive Disorder, sponsored by San Francisco Veterans Affairs Medical Center.
- Recruiting
- Registry status
- NA
- Development phase
- 45
- Enrollment target
- 1
- Study location
NCT05194098: Recruiting NA study of Major Depressive Disorder, sponsored by San Francisco Veterans Affairs Medical Center.
NCT05194098 is a NA study of Major Depressive Disorder that is actively recruiting participants, run by San Francisco Veterans Affairs Medical Center. The registered enrollment target is 45 participants, below the 377-participant average among 282 other Major Depressive Disorder trials with a reported enrollment target (88% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05194098, a NA study of Major Depressive Disorder, is actively recruiting participants, sponsored by San Francisco Veterans Affairs Medical Center.
- RECRUITING
- Registry status
- NA
- Development phase
- 45 participants
- Enrollment target
- 1
- Study location
Study Summary
Depression is a leading cause of morbidity and mortality, conferring substantial healthcare and societal costs. By studying methods to non-invasively target neural circuitry involved in reward responsivity, information generated by this project will improve understanding of the circuit alterations that underlie motivation and pleasure deficits in depression, and could also lead to the development of biologically-based markers of neurostimulation-based treatment response.
Conditions Studied
Interventions
- DEVICE TMS: single session intermittent theta burst stimulation (iTBS) to dorsomedial prefrontal target in individuals with major depressive disorder, via MagVenture MagPro R30 device / Cool-DB80 A/P coil
- DEVICE SHAM (inactive) TMS stimulation
Study Locations (1)
California
- San Francisco VA Medical Center - San Francisco
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 45 participants |
| Start Date | 2021-10-01 |
| Est. Completion | 2024-09-30 |
| Phase | NA |
What NCT05194098 shows while recruiting
NCT05194098 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 45 participants, a relatively small participant target, below the 377-participant average among 282 other Major Depressive Disorder trials with a reported enrollment target (88% lower).
The record links to 1 condition, with Major Depressive Disorder appearing as the primary indexed condition, and to 2 interventions - of which TMS: single session intermittent theta burst stimulation (iTBS) to dorsomedial prefrontal target in individuals with major depressive disorder, via MagVenture MagPro R30 device / Cool-DB80 A/P coil is the first listed.
NCT05194098 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT05194098 about?
NCT05194098 is a clinical study titled "Using Electrophysiology to Index Non-invasive Brain Stimulation Effects on Reward System Functioning in Depression". Depression is a leading cause of morbidity and mortality, conferring substantial healthcare and societal costs. By studying methods to non-invasively target neural circuitry involved in reward responsivity, information generated by this project will improve understanding of the circuit alterations t...
What is the current status of trial NCT05194098?
This trial is currently recruiting. It is a NA study. The enrollment target is 45 participants. The study started on 2021-10-01. Estimated completion is 2024-09-30.
What conditions does trial NCT05194098 study?
This clinical trial studies the following conditions: Major Depressive Disorder.
What interventions are being tested in trial NCT05194098?
The interventions under investigation include: TMS: single session intermittent theta burst stimulation (iTBS) to dorsomedial prefrontal target in individuals with major depressive disorder, via MagVenture MagPro R30 device / Cool-DB80 A/P coil (DEVICE), SHAM (inactive) TMS stimulation (DEVICE).
Who is sponsoring clinical trial NCT05194098?
This trial is sponsored by San Francisco Veterans Affairs Medical Center, which has 15 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05194098 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Major Depressive Disorder
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05194098's enrollment target sits among peer trials
45 191st of 282 higher than 92 of 282 other Major Depressive Disorder trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Major Depressive Disorder trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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