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Study of JDQ443 in Comparison With Docetaxel in Participants With Locally Advanced or Metastatic KRAS G12C Mutant Non-small Cell Lung Cancer
NCT05132075 · View on ClinicalTrials.gov ↗
Study Summary
This is a phase III randomized open label study designed to compare JDQ443 as monotherapy to docetaxel in participants with advanced non-small cell lung cancer (NSCLC) harboring a KRAS G12C mutation who have been previously treated with a platinum-based chemotherapy and immune checkpoint inhibitor therapy either in sequence or in combination.
Conditions Studied
Interventions
- DRUG docetaxel
- DRUG JDQ443
Study Locations (20)
Other
- Novartis Investigative Site — Chongqing
- Novartis Investigative Site — Turku
- Novartis Investigative Site — Athens
Buenos Aires
- Novartis Investigative Site — CABA
- Novartis Investigative Site — Pilar
Queensland
- Novartis Investigative Site — Auchenflower
- Novartis Investigative Site — South Brisbane
Quebec
- Novartis Investigative Site — Montreal
- Novartis Investigative Site — Sherbrooke
Guangdong
- Novartis Investigative Site — Guangzhou
- Novartis Investigative Site — Guangzhou
Washington
- Valley Medical Center Research — Renton
Beijing Municipality
- Novartis Investigative Site — Beijing
Fujian
- Novartis Investigative Site — Fuzhou
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 95 participants |
| Start Date | 2022-06-15 |
| Est. Completion | 2026-03-30 |
| Phase | Phase 3 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05132075
The ClinicalTrials.gov registry entry for NCT05132075 describes a study currently listed as active not recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 95 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Novartis Pharmaceuticals, which has 792 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Non-Small Cell Lung Cancer appearing as the primary indexed condition, and to 2 interventions — of which docetaxel is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT05132075 reports 20 study locations spanning 14 distinct geographic areas — top geographies include Other, Buenos Aires, Queensland. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT05132075 about?
NCT05132075 is a clinical study titled "Study of JDQ443 in Comparison With Docetaxel in Participants With Locally Advanced or Metastatic KRAS G12C Mutant Non-small Cell Lung Cancer". This is a phase III randomized open label study designed to compare JDQ443 as monotherapy to docetaxel in participants with advanced non-small cell lung cancer (NSCLC) harboring a KRAS G12C mutation who have been previously treated with a platinum-based chemotherapy and immune checkpoint inhibitor t...
What is the current status of trial NCT05132075?
This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 95 participants. The study started on 2022-06-15. Estimated completion is 2026-03-30.
What conditions does trial NCT05132075 study?
This clinical trial studies the following conditions: Non-Small Cell Lung Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT05132075?
The interventions under investigation include: docetaxel (DRUG), JDQ443 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT05132075?
This trial is sponsored by Novartis Pharmaceuticals, which has 792 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT05132075 being conducted?
This trial has 20 study locations across Washington, Buenos Aires, Queensland, Quebec, Beijing Municipality. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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