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NCT05086393 · ClinicalTrials.gov registry record · Phase 4
Duloxetine RCT on Postop TKA Outcomes
A Phase 4 study, sponsored by Rush University Medical Center.
- Completed
- Registry status
- Phase 4
- Development phase
- 241
- Enrollment target
NCT05086393: Completed Phase 4 study, sponsored by Rush University Medical Center.
NCT05086393 is a Phase 4 study that has completed, run by Rush University Medical Center. The registered enrollment target is 241 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (53% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05086393, a Phase 4 study, has completed, sponsored by Rush University Medical Center.
- COMPLETED
- Registry status
- Phase 4
- Development phase
- 241 participants
- Enrollment target
Study Summary
The aim of this study is to determine if duloxetine is associated with differences in post-operative pain, patient-reported outcome measures, and opioid consumption in patients undergoing primary total knee arthroplasty compared to patients who do not receive the medication. If so, duloxetine has the potential to become widely incorporated into the multi-modal analgesic regimen given to patients following knee replacements.
Primary Outcome
Measuring in morphine equivalents, collect daily data on opioid consumption for each participant
Interventions
- DRUG Duloxetine
- DRUG Placebos
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 241 participants |
| Start Date | 2021-11-01 |
| Est. Completion | 2025-07-23 |
| Phase | Phase 4 |
What the finished NCT05086393 record still lists
NCT05086393 is an interventional study that assigns participants to a tested intervention. The registered 241 participants enrollment target is mid-sized for trials with a published cap, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (53% lower).
The record links to 0 conditions, and to 2 interventions - of which Duloxetine is the first listed.
NCT05086393 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05086393 about?
NCT05086393 is a clinical study titled "Duloxetine RCT on Postop TKA Outcomes". The aim of this study is to determine if duloxetine is associated with differences in post-operative pain, patient-reported outcome measures, and opioid consumption in patients undergoing primary total knee arthroplasty compared to patients who do not receive the medication. If so, duloxetine has th...
What is the current status of trial NCT05086393?
This trial is currently completed. It is a Phase 4 study. The enrollment target is 241 participants. The study started on 2021-11-01. Estimated completion is 2025-07-23.
What interventions are being tested in trial NCT05086393?
The interventions under investigation include: Duloxetine (DRUG), Placebos (DRUG).
Who is sponsoring clinical trial NCT05086393?
This trial is sponsored by Rush University Medical Center, which has 320 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05086393's enrollment target sits among peer trials
241 360th of 2000 higher than 1,641 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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