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NCT05069740 · ClinicalTrials.gov registry record · Early Phase 1

Endometriosis and Microvascular Dysfunction: Role of Inflammation

A Early Phase 1 study of Endometriosis, sponsored by Penn State University.

Recruiting
Registry status
Early Phase 1
Development phase
24
Enrollment target
1
Study location

NCT05069740 is a Early Phase 1 study of Endometriosis that is actively recruiting participants, run by Penn State University. The registered enrollment target is 24 participants, below the 264-participant average among 48 other Endometriosis trials with a reported enrollment target (91% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT05069740, a Early Phase 1 study of Endometriosis, is actively recruiting participants, sponsored by Penn State University.

RECRUITING
Registry status
Early Phase 1
Development phase
24 participants
Enrollment target
1
Study location

Study Summary

The purpose of this study is to better understand the underlying mechanisms associated with elevated cardiovascular disease risk in women with endometriosis, and to measure the effectiveness of emerging endometriosis treatments on outcomes specific to cardiovascular dysfunction. Epidemiologic data demonstrate a clear association between endometriosis, reproductive risk factors, inflammation and cardiovascular (CV) risk. Circulating factors, low-density lipoprotein (LDL) and oxidized LDL (oxLDL), are two of many biomarkers of cardiovascular and inflammatory disease of endometriosis. An important signaling mechanism through which circulating LDL and oxLDL act is the lectin-like oxidized LDL receptor (LOX-1). LOX-1 signal transduction functionally results in pronounced endothelial dysfunction, a hallmark of CV. The investigators hypothesis that one factor mediating the elevated risk of cardiovascular disease in endometriosis is systemic inflammation and activation of LOX-1 receptor mechanisms.

Conditions Studied

Endometriosis

Interventions

  • DRUG Placebo
  • DRUG Salsalate Pill

Study Locations (1)

Pennsylvania

  • The Pennsylvania State University - University Park

Trial Details

FieldValue
Enrollment Target 24 participants
Start Date 2022-01-01
Est. Completion 2026-12-31
Phase Early Phase 1

Sponsor

Penn State University

219 total trials

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What the Registry Record Tells You About NCT05069740

The ClinicalTrials.gov registry entry for NCT05069740 describes a study currently listed as recruiting, categorized as Early Phase 1. The registered enrollment target is 24 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 264-participant average among 48 other Endometriosis trials with a reported enrollment target (91% lower). The listed sponsor is Penn State University, which has 219 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with Endometriosis appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.

NCT05069740 reports 1 study location spanning 1 distinct geographic area - top geographies include Pennsylvania.

Frequently Asked Questions

What is clinical trial NCT05069740 about?

NCT05069740 is a clinical study titled "Endometriosis and Microvascular Dysfunction: Role of Inflammation". The purpose of this study is to better understand the underlying mechanisms associated with elevated cardiovascular disease risk in women with endometriosis, and to measure the effectiveness of emerging endometriosis treatments on outcomes specific to cardiovascular dysfunction. Epidemiologic data ...

What is the current status of trial NCT05069740?

This trial is currently recruiting. It is a Early Phase 1 study. The enrollment target is 24 participants. The study started on 2022-01-01. Estimated completion is 2026-12-31.

What conditions does trial NCT05069740 study?

This clinical trial studies the following conditions: Endometriosis.

What interventions are being tested in trial NCT05069740?

The interventions under investigation include: Placebo (DRUG), Salsalate Pill (DRUG).

Who is sponsoring clinical trial NCT05069740?

This trial is sponsored by Penn State University, which has 219 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT05069740 being conducted?

This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.