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NCT04938960 · ClinicalTrials.gov registry record
Identification of Non-gal, Non-HLA Antigens in Patients Implanted With Xenogenic Material
A clinical trial, sponsored by Mayo Clinic.
- Completed
- Registry status
- 197
- Enrollment target
NCT04938960: Completed study, sponsored by Mayo Clinic.
NCT04938960 is a clinical trial that has completed, run by Mayo Clinic. The registered enrollment target is 197 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04938960 has completed, sponsored by Mayo Clinic.
- COMPLETED
- Registry status
- 197 participants
- Enrollment target
Study Summary
This study involves collecting serum samples from patients presenting for aortic valve replacement at Mayo Clinic, Rochester, MN. Serum samples will be collected pre-op, between 2 weeks and 3 months, between 3-11 months (optional), and between 12-18 months post-operatively. The patients antibodies in these serum samples will be used to capture proteins from the same type of tissue their replacement heart valves are made from (i.e., bovine/porcine pericardium - a non-human tissue which is currently used to make glutaraldehyde-fixed heart valves). The captured proteins will be identified, and compared over time (i.e., 0, 1, 3 and 12 months) to determine which proteins (i.e., antigens) in bovine/porcine pericardium that the patient is mounting an immune response towards.
Primary Outcome
The captured proteins will be identified, and compared over time (i.e., pre-op, between 2 weeks and 3 months, between 3-11 months (optional), and 12-18 months post-operatively) to determine which proteins (i.e., antigens) in bovine/porcine pericardium that the patient is mounting an immune response towards.
Interventions
- DIAGNOSTIC_TEST blood draw
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 197 participants |
| Start Date | 2021-07-01 |
| Est. Completion | 2024-09-05 |
What the finished NCT04938960 record still lists
NCT04938960 is an observational study that tracks outcomes without assigning an intervention. The registered 197 participants enrollment target is mid-sized for trials with a published cap.
The record links to 0 conditions, and to 1 intervention - of which blood draw is the first listed.
NCT04938960 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04938960 about?
NCT04938960 is a clinical study titled "Identification of Non-gal, Non-HLA Antigens in Patients Implanted With Xenogenic Material". This study involves collecting serum samples from patients presenting for aortic valve replacement at Mayo Clinic, Rochester, MN. Serum samples will be collected pre-op, between 2 weeks and 3 months, between 3-11 months (optional), and between 12-18 months post-operatively. The patients antibodies i...
What is the current status of trial NCT04938960?
This trial is currently completed. The enrollment target is 197 participants. The study started on 2021-07-01. Estimated completion is 2024-09-05.
What interventions are being tested in trial NCT04938960?
The interventions under investigation include: blood draw (DIAGNOSTIC_TEST).
Who is sponsoring clinical trial NCT04938960?
This trial is sponsored by Mayo Clinic, which has 2,844 total clinical trials registered on ClinicalTrials.gov.
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