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NCT04923685 · ClinicalTrials.gov registry record
MicroRNA Correlates of Childhood Maltreatment and Suicidality
A clinical trial of Major Depressive Disorder and Suicidal Ideation, sponsored by University of Alabama at Birmingham.
- Recruiting
- Registry status
- 450
- Enrollment target
- 2
- Study locations
NCT04923685: Recruiting study of Major Depressive Disorder and Suicidal Ideation, sponsored by University of Alabama at Birmingham.
NCT04923685 is a study of Major Depressive Disorder and Suicidal Ideation that is actively recruiting participants, run by University of Alabama at Birmingham. The registered enrollment target is 450 participants, above the 375-participant average among 282 other Major Depressive Disorder trials with a reported enrollment target (20% higher). The trial reports 2 study locations across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04923685, a study of Major Depressive Disorder and Suicidal Ideation, is actively recruiting participants, sponsored by University of Alabama at Birmingham.
- RECRUITING
- Registry status
- 450 participants
- Enrollment target
- 2
- Study locations
Study Summary
This is a research study to find out if childhood trauma and stress are associated with depression or suicidal risk. The study will assess the effects of both short-term and long-term stress on biomarker (e.g. miRNA \[MiRNA\]) levels. miRNAs are a type of RNA (genetic material that is translated into protein) that are found in throughout the body and blood. They are called microRNA because their size is much smaller than typical RNA molecules. miRNAs are highly responsive to environment. This responsiveness is reflected in their expression in individuals who are affected by environment such as stress. The investigators are gathering genetic material, including DNA and RNA, from each participant. The RNA will be taken from the small vesicles and cells in the participant's blood and analyzed. The vesicles are small objects that occur normally in the blood and that contain RNA. This information may help us to understand the cause of mental illness and to improve medical and psychiatric care in the future. There will be 450 participants enrolled in this study.
Primary Outcome
MiRNAs methylation levels will be examined
Conditions Studied
Interventions
- OTHER Trier Social Stress Test
Study Locations (2)
Alabama
- University of Alabama at Birmingham - Birmingham
- UAB Huntsville Regional Medical Campus - Huntsville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 450 participants |
| Start Date | 2021-02-26 |
| Est. Completion | 2026-09 |
What NCT04923685 shows while recruiting
NCT04923685 is an observational study that tracks outcomes without assigning an intervention. The registered 450 participants enrollment target is mid-sized for trials with a published cap, above the 375-participant average among 282 other Major Depressive Disorder trials with a reported enrollment target (20% higher).
The record links to 2 conditions, with Major Depressive Disorder appearing as the primary indexed condition, and to 1 intervention - of which Trier Social Stress Test is the first listed.
NCT04923685 reports a single indexed study location in Alabama.
Frequently Asked Questions
What is clinical trial NCT04923685 about?
NCT04923685 is a clinical study titled "MicroRNA Correlates of Childhood Maltreatment and Suicidality". This is a research study to find out if childhood trauma and stress are associated with depression or suicidal risk. The study will assess the effects of both short-term and long-term stress on biomarker (e.g. miRNA \[MiRNA\]) levels. miRNAs are a type of RNA (genetic material that is translated int...
What is the current status of trial NCT04923685?
This trial is currently recruiting. The enrollment target is 450 participants. The study started on 2021-02-26. Estimated completion is 2026-09.
What conditions does trial NCT04923685 study?
This clinical trial studies the following conditions: Major Depressive Disorder, Suicidal Ideation.
What interventions are being tested in trial NCT04923685?
The interventions under investigation include: Trier Social Stress Test (OTHER).
Who is sponsoring clinical trial NCT04923685?
This trial is sponsored by University of Alabama at Birmingham, which has 1,160 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04923685 being conducted?
This trial has 2 study locations across Alabama. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04923685's enrollment target sits among peer trials
450 42nd of 282 higher than 239 of 282 other Major Depressive Disorder trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Major Depressive Disorder trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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