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NCT04906135 · ClinicalTrials.gov registry record · NA
Auditory Neural Function in Implanted Patients With Usher Syndrome
A NA study, sponsored by Ohio State University.
- Completed
- Registry status
- NA
- Development phase
- 29
- Enrollment target
NCT04906135: Completed NA study, sponsored by Ohio State University.
NCT04906135 is a NA study that has completed, run by Ohio State University. The registered enrollment target is 29 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04906135, a NA study, has completed, sponsored by Ohio State University.
- COMPLETED
- Registry status
- NA
- Development phase
- 29 participants
- Enrollment target
Study Summary
Usher syndrome (USH) causes extensive degeneration in the cochlear nerve (CN), especially in CN fibers innervating the base of the cochlea. As the first step toward developing evidence-based practice for managing implant patients with USH, this study evaluates local neural health, as well as the neural encoding of temporal and spectral cues at the CN in implanted patients with USH. Aim 1 will determine local CN health in patients with USH by assessing the sensitivity of the electrically evoked compound action potential to changes in interphase gap and pulse polarity. Aim 2 will determine group differences in neural encoding of temporal and spectral cues at the CN between patients with USH and patients with idiopathic hearing loss. Aim 3 will use supervised machine learning techniques to develop an objective tool for assessing the electrode-neuron interface at individual electrode locations.
Primary Outcome
The primary outcome measure is the neural response generated by the electrically-stimulated cochlear nerve, which can be considered a health-related, biomedical outcome.
Interventions
- OTHER Experimental manipulation of stimulation parameters
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 29 participants |
| Start Date | 2021-10-01 |
| Est. Completion | 2025-07-11 |
| Phase | NA |
What the finished NCT04906135 record still lists
NCT04906135 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 29 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower).
The record links to 0 conditions, and to 1 intervention - of which Experimental manipulation of stimulation parameters is the first listed.
NCT04906135 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04906135 about?
NCT04906135 is a clinical study titled "Auditory Neural Function in Implanted Patients With Usher Syndrome". Usher syndrome (USH) causes extensive degeneration in the cochlear nerve (CN), especially in CN fibers innervating the base of the cochlea. As the first step toward developing evidence-based practice for managing implant patients with USH, this study evaluates local neural health, as well as the neu...
What is the current status of trial NCT04906135?
This trial is currently completed. It is a NA study. The enrollment target is 29 participants. The study started on 2021-10-01. Estimated completion is 2025-07-11.
What interventions are being tested in trial NCT04906135?
The interventions under investigation include: Experimental manipulation of stimulation parameters (OTHER).
Who is sponsoring clinical trial NCT04906135?
This trial is sponsored by Ohio State University, which has 552 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04906135's enrollment target sits among peer trials
29 1702nd of 2000 higher than 297 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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