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ACTIVE NOT RECRUITING Phase 2

Study of VIR-2218, VIR-3434, and/or PEG-IFNα in Subjects With Chronic Hepatitis B Virus Infection

NCT04856085 · View on ClinicalTrials.gov ↗

Study Summary

This is a phase 2 study in which participants with chronic hepatitis B virus (HBV) infection will receive VIR-2218, VIR-3434 and/or PEG-IFNα and be assessed for safety, tolerability, and efficacy

Conditions Studied

Interventions

  • DRUG VIR-2218
  • DRUG VIR-3434
  • DRUG PEG-IFNα

Study Locations (20)

Other

  • Investigative Site — Toronto
  • Investigative Site — Toronto
  • Investigative Site — Vancouver
  • Investigative Site — Frankfurt
  • Investigative Site — Hanover
  • Investigative Site — Mannheim
  • Investigative Site — Hong Kong
  • Investigative Site — Kuala Lumpur
  • Investigative Site — Chisinau
  • Investigative Site — Auckland
  • Investigative Site — Auckland
  • Investigative Site — Hamilton
  • Investigative Site — Tauranga

Florida

  • Investigative Site — Miami
  • Investigative Site — Orlando

California

  • Investigative Site — San Francisco

Maryland

  • Investigative Site — Baltimore

New Jersey

  • Investigative Site — Hillsborough

Shatin

  • Investigative Site — Hong Kong

Tai Po District

  • Investigative Site — Hong Kong

Trial Details

FieldValue
Enrollment Target 244 participants
Start Date 2021-07-11
Est. Completion 2026-03
Phase Phase 2

Sponsor

Vir Biotechnology

7 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT04856085

The ClinicalTrials.gov registry entry for NCT04856085 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 244 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Vir Biotechnology, which has 7 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Hepatitis B, Chronic appearing as the primary indexed condition, and to 3 interventions — of which VIR-2218 is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT04856085 reports 20 study locations spanning 7 distinct geographic areas — top geographies include Other, Florida, California. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT04856085 about?

NCT04856085 is a clinical study titled "Study of VIR-2218, VIR-3434, and/or PEG-IFNα in Subjects With Chronic Hepatitis B Virus Infection". This is a phase 2 study in which participants with chronic hepatitis B virus (HBV) infection will receive VIR-2218, VIR-3434 and/or PEG-IFNα and be assessed for safety, tolerability, and efficacy

What is the current status of trial NCT04856085?

This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 244 participants. The study started on 2021-07-11. Estimated completion is 2026-03.

What conditions does trial NCT04856085 study?

This clinical trial studies the following conditions: Hepatitis B, Chronic. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT04856085?

The interventions under investigation include: VIR-2218 (DRUG), VIR-3434 (DRUG), PEG-IFNα (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT04856085?

This trial is sponsored by Vir Biotechnology, which has 7 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT04856085 being conducted?

This trial has 20 study locations across California, Florida, Maryland, New Jersey, Shatin. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial