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NCT04766814 · ClinicalTrials.gov registry record
Epigenetic Analysis of Regulation of the Inflammasome-activating NLRP3 Gene in Monocytes From Atrial Fibrillation Patients and Controls
A clinical trial, sponsored by Tulane University.
- Completed
- Registry status
- 29
- Enrollment target
NCT04766814 is a clinical trial that has completed, run by Tulane University. The registered enrollment target is 29 participants.
The verdict
NCT04766814 has completed, sponsored by Tulane University.
- COMPLETED
- Registry status
- 29 participants
- Enrollment target
Study Summary
The study will analyze blood from volunteers to determine whether there is an underlying epigenetic cause of the inflammation of the heart associated with atrial fibrillation (AF) and its progression with age. Confirming the regions of epigenetic elements associated with upregulation of the inflammatory genes will help the investigators in identifying target sites for developing future therapeutic interventions. The investigators propose to confirm the monocyte-cell type specific DNA methylation profile of NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) and determine the age-related and AF-related changes in DNA methylation and expression of NLRP3 in monocytes. This study will provide insights into the epigenetic regulation of NLRP3 in young and elderly patients, as well as in AF patients vs. controls which will help in devising methods of modulating NLRP3 expression and decreasing cardiac fibrosis progression.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 29 participants |
| Start Date | 2021-10-22 |
| Est. Completion | 2024-02-16 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04766814
The ClinicalTrials.gov registry entry for NCT04766814 describes a study currently listed as completed, categorized as an unspecified phase. The registered enrollment target is 29 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Tulane University, which has 73 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 0 interventions.
NCT04766814 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT04766814 about?
NCT04766814 is a clinical study titled "Epigenetic Analysis of Regulation of the Inflammasome-activating NLRP3 Gene in Monocytes From Atrial Fibrillation Patients and Controls". The study will analyze blood from volunteers to determine whether there is an underlying epigenetic cause of the inflammation of the heart associated with atrial fibrillation (AF) and its progression with age. Confirming the regions of epigenetic elements associated with upregulation of the inflamma...
What is the current status of trial NCT04766814?
This trial is currently completed. The enrollment target is 29 participants. The study started on 2021-10-22. Estimated completion is 2024-02-16.
Who is sponsoring clinical trial NCT04766814?
This trial is sponsored by Tulane University, which has 73 total clinical trials registered on ClinicalTrials.gov.
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