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NCT04742387 · ClinicalTrials.gov registry record
Assessment of Bone Mineral Density in People Living With HIV and KSHV Associated Malignancies: A Retrospective Longitudinal Analysis
A clinical trial of Kaposi Sarcoma and Primary Effusion Lymphoma, sponsored by National Cancer Institute (NCI).
- Active
- Registry status
- 40
- Enrollment target
- 1
- Study location
NCT04742387: Active study of Kaposi Sarcoma and Primary Effusion Lymphoma, sponsored by National Cancer Institute (NCI).
NCT04742387 is a study of Kaposi Sarcoma and Primary Effusion Lymphoma that is active but no longer recruiting, run by National Cancer Institute (NCI). The registered enrollment target is 40 participants, below the 99-participant average among 13 other Kaposi Sarcoma trials with a reported enrollment target (60% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04742387, a study of Kaposi Sarcoma and Primary Effusion Lymphoma, is active but no longer recruiting, sponsored by National Cancer Institute (NCI).
- ACTIVE NOT RECRUITING
- Registry status
- 40 participants
- Enrollment target
- 1
- Study location
Study Summary
Background: Some people with human immunodeficiency virus (HIV) are on antiretroviral therapy (ART). Their cells have shown to age faster than expected. This puts them at higher risk for a range of age-related diseases about 10 years sooner than people who do not have HIV. Low bone mineral density (BMD) is common in people with HIV. This means their risk of fractures is increased. People with HIV also have a higher risk for cancers caused by Kaposi's sarcoma herpesvirus (KSHV) than people who do not have HIV. Much of the data on bone loss related to cancer and cancer treatments has been gathered from people who do not have HIV. Researchers want to learn more about the rate of bone loss in people with HIV/AIDS and KSHV associated cancers. Objective: To learn the factors that are linked to BMD loss in people with HIV and KSHV associated cancers from imaging performed as part of NIH studies. Eligibility: Adults with HIV and Kaposi s sarcoma who got ART and cancer chemotherapy at NIH from 1/1/2005 to 12/1/2020. Design: Participants' records will be chosen from studies that were conducted from 1/1/2005 to 12/1/2020. This study will include participants who had at least 2 CT scans. Some participants may have opted out of the future use of their data. If so, their records will not be used. This study will use data collected at NIH. Data taken from CT scans will be used to measure BMD. Study results may be published. This study will last about 2 years.
Primary Outcome
To determine variables that are associated with BMD loss in participants with HIV and KSHV associated malignancies from retrospective imaging performed as part of clinical research protocols
Conditions Studied
Study Locations (1)
Maryland
- National Cancer Institute (NCI) - Bethesda
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2021-02-04 |
| Est. Completion | 2027-12-31 |
What the registry record for NCT04742387 still lists
NCT04742387 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 40 participants, a relatively small participant target, below the 99-participant average among 13 other Kaposi Sarcoma trials with a reported enrollment target (60% lower).
The record links to 4 conditions, with Kaposi Sarcoma appearing as the primary indexed condition, and to 0 interventions.
NCT04742387 reports a single indexed study location in Maryland.
Frequently Asked Questions
What is clinical trial NCT04742387 about?
NCT04742387 is a clinical study titled "Assessment of Bone Mineral Density in People Living With HIV and KSHV Associated Malignancies: A Retrospective Longitudinal Analysis". Background: Some people with human immunodeficiency virus (HIV) are on antiretroviral therapy (ART). Their cells have shown to age faster than expected. This puts them at higher risk for a range of age-related diseases about 10 years sooner than people who do not have HIV. Low bone mineral density ...
What is the current status of trial NCT04742387?
This trial is currently active not recruiting. The enrollment target is 40 participants. The study started on 2021-02-04. Estimated completion is 2027-12-31.
What conditions does trial NCT04742387 study?
This clinical trial studies the following conditions: Kaposi Sarcoma, Primary Effusion Lymphoma, KSHV Associated Multicentric Castleman Disease, IL-6 Related KSHV Associated Cytokine Syndrome.
Who is sponsoring clinical trial NCT04742387?
This trial is sponsored by National Cancer Institute (NCI), which has 3,257 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04742387 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Kaposi Sarcoma
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04742387's enrollment target sits among peer trials
40 12th of 13 higher than 2 of 13 other Kaposi Sarcoma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Kaposi Sarcoma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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