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NCT04671212 · ClinicalTrials.gov registry record
Discarded Bone Marrow for Hematology Research
A clinical trial of Hemoglobinopathies, sponsored by St. Jude Children's Research Hospital.
- Recruiting
- Registry status
- 50
- Enrollment target
- 1
- Study location
NCT04671212: Recruiting study of Hemoglobinopathies, sponsored by St. Jude Children's Research Hospital.
NCT04671212 is a study of Hemoglobinopathies that is actively recruiting participants, run by St. Jude Children's Research Hospital. The registered enrollment target is 50 participants, below the 1,801-participant average among 17 other Hemoglobinopathies trials with a reported enrollment target (97% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04671212, a study of Hemoglobinopathies, is actively recruiting participants, sponsored by St. Jude Children's Research Hospital.
- RECRUITING
- Registry status
- 50 participants
- Enrollment target
- 1
- Study location
Study Summary
The primary objective of this study is to establish a mechanism to obtain discarded bone marrow-containing bone samples from hemoglobinopathy, as well as non-hemoglobinopathy individuals. The processing of samples will help to understand how best to manipulate HSPC's from hemoglobinopathy patients with gene therapy and gene technologies in the laboratory environment. It will also allow us to establish a reservoir of samples that can be studied in the future to assess cellular function and fitness for transplant. Secondary objectives * To develop gene transfer and gene editing strategies as potentially curative therapy for hemoglobinopathies (e.g. sickle cell disease (SCD) and β-thalassemia). * To develop a drug treatment strategy which elevates the expression of fetal hemoglobin to a potentially curative level for hemoglobinopathies. * To examine the biology of bone marrow cells isolated from patients with hemoglobinopathies.
Primary Outcome
Discarded bone marrow-containing bone samples will be collected for use in research; The processing of samples will help to understand how best to manipulate HSPC's from hemoglobinopathy patients with gene therapy and gene technologies in the laboratory environment. It will also allow us to establish a reservoir of samples that can be studied in the future to assess cellular function and fitness for transplant. Samples may be subject to comprehensive assessment of hematopoietic activity using ti
Conditions Studied
Study Locations (1)
Tennessee
- St. Jude Children's Research Hospital - Memphis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 50 participants |
| Start Date | 2022-07-26 |
| Est. Completion | 2035-01 |
What NCT04671212 shows while recruiting
NCT04671212 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 50 participants, a relatively small participant target, below the 1,801-participant average among 17 other Hemoglobinopathies trials with a reported enrollment target (97% lower).
The record links to 1 condition, with Hemoglobinopathies appearing as the primary indexed condition, and to 0 interventions.
NCT04671212 reports a single indexed study location in Tennessee.
Frequently Asked Questions
What is clinical trial NCT04671212 about?
NCT04671212 is a clinical study titled "Discarded Bone Marrow for Hematology Research". The primary objective of this study is to establish a mechanism to obtain discarded bone marrow-containing bone samples from hemoglobinopathy, as well as non-hemoglobinopathy individuals. The processing of samples will help to understand how best to manipulate HSPC's from hemoglobinopathy patients w...
What is the current status of trial NCT04671212?
This trial is currently recruiting. The enrollment target is 50 participants. The study started on 2022-07-26. Estimated completion is 2035-01.
What conditions does trial NCT04671212 study?
This clinical trial studies the following conditions: Hemoglobinopathies.
Who is sponsoring clinical trial NCT04671212?
This trial is sponsored by St. Jude Children's Research Hospital, which has 410 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04671212 being conducted?
This trial has 1 study location across Tennessee. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Hemoglobinopathies
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04671212's enrollment target sits among peer trials
50 5th of 17 higher than 13 of 17 other Hemoglobinopathies trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Hemoglobinopathies trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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