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NCT04662658 · ClinicalTrials.gov registry record · Phase 1
Hyperpolarized Xenon-129 MR Imaging of the Lung
A Phase 1 study of E-Cig Use, sponsored by University of Virginia.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 24
- Enrollment target
- 1
- Study location
NCT04662658: Recruiting Phase 1 study of E-Cig Use, sponsored by University of Virginia.
NCT04662658 is a Phase 1 study of E-Cig Use that is actively recruiting participants, run by University of Virginia. The registered enrollment target is 24 participants, below the 149-participant average among 9 other E-Cig Use trials with a reported enrollment target (84% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04662658, a Phase 1 study of E-Cig Use, is actively recruiting participants, sponsored by University of Virginia.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 24 participants
- Enrollment target
- 1
- Study location
Study Summary
Over the past 10 years, electronic cigarettes (e-cigarettes, EC) have been commercialized as a "less harmful" alternative to traditional cigarettes.1,2 However, e-cigarettes are believed to cause pulmonary epithelial, endothelial and vascular dysfunction, and to cause murine phenotypes similar to those of human COPD. Recently, "spiked" vape juice has been linked to severe lung damage. Unfortunately, the effects of e-cigarettes on the human lungs are still poorly understood, especially in healthy young adults. Therefore, establishing the health effects of e-cigarettes in humans is of paramount importance to guide medical and regulatory decision making. Its widespread use and immense popularity among teenagers and young adults have caused major concern given potentially significant addictive and detrimental long-term health effects.
Primary Outcome
To measure the pulmonary physiologic effects of e-cigarette use in young adults with less than a 5 pack-year history of smoking traditional cigarettes.
Conditions Studied
Interventions
- DRUG Hyperpolarized Xenon -129 MRI
Study Locations (1)
Virginia
- Snyder Building 480 Ray C. Hunt Drive - Charlottesville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 24 participants |
| Start Date | 2020-11-05 |
| Est. Completion | 2025-12 |
| Phase | Phase 1 |
What NCT04662658 shows while recruiting
NCT04662658 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 24 participants, a relatively small participant target, below the 149-participant average among 9 other E-Cig Use trials with a reported enrollment target (84% lower).
The record links to 1 condition, with E-Cig Use appearing as the primary indexed condition, and to 1 intervention - of which Hyperpolarized Xenon -129 MRI is the first listed.
NCT04662658 reports a single indexed study location in Virginia.
Frequently Asked Questions
What is clinical trial NCT04662658 about?
NCT04662658 is a clinical study titled "Hyperpolarized Xenon-129 MR Imaging of the Lung". Over the past 10 years, electronic cigarettes (e-cigarettes, EC) have been commercialized as a "less harmful" alternative to traditional cigarettes.1,2 However, e-cigarettes are believed to cause pulmonary epithelial, endothelial and vascular dysfunction, and to cause murine phenotypes similar to th...
What is the current status of trial NCT04662658?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 24 participants. The study started on 2020-11-05. Estimated completion is 2025-12.
What conditions does trial NCT04662658 study?
This clinical trial studies the following conditions: E-Cig Use.
What interventions are being tested in trial NCT04662658?
The interventions under investigation include: Hyperpolarized Xenon -129 MRI (DRUG).
Who is sponsoring clinical trial NCT04662658?
This trial is sponsored by University of Virginia, which has 449 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04662658 being conducted?
This trial has 1 study location across Virginia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for E-Cig Use
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04662658's enrollment target sits among peer trials
24 10th of 9 the lowest of 9 other E-Cig Use trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other E-Cig Use trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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