Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

RECRUITING Phase 2

Ramucirumab and Trifluridine/Tipiracil or Paclitaxel for the Treatment of Patients With Previously Treated Advanced Gastric or Gastroesophageal Junction Cancer

NCT04660760 · View on ClinicalTrials.gov ↗

Study Summary

This phase II trial studies the effect of the combination of ramucirumab and trifluridine/tipiracil or paclitaxel in treating patients with previously treated gastric or gastroesophageal junction cancer that has spread to other places in the body (advanced). Ramucirumab may damage tumor cells by targeting new blood vessel formation. Trifluridine/tipiracil is a chemotherapy pill and that may damage tumor cells by damaging their deoxyribonucleic acid (DNA). Paclitaxel may block cell growth by stopping cell division which may kill tumor cells. Giving ramucirumab and trifluridine/tipiracil will not be worse than ramucirumab and paclitaxel in treating gastric or gastroesophageal junction cancer.

Interventions

  • OTHER Quality-of-Life Assessment
  • DRUG Paclitaxel
  • BIOLOGICAL Ramucirumab
  • DRUG Trifluridine and Tipiracil Hydrochloride

Study Locations (15)

Arizona

  • Mayo Clinic in Arizona — Scottsdale
  • Arizona Clinical Research Center — Tucson

Florida

  • Mayo Clinic in Florida — Jacksonville
  • Cleveland Clinic-Weston — Weston

Wisconsin

  • Saint Vincent Hospital Cancer Center Green Bay — Green Bay
  • Aurora Cancer Care-Milwaukee West — Wauwatosa

Alabama

  • University of Alabama at Birmingham Cancer Center — Birmingham

California

  • USC / Norris Comprehensive Cancer Center — Los Angeles

Georgia

  • Emory University Hospital/Winship Cancer Institute — Atlanta

Illinois

  • Carle Cancer Center NCI Community Oncology Research Program — Urbana

Iowa

  • University of Iowa/Holden Comprehensive Cancer Center — Iowa City

Trial Details

FieldValue
Enrollment Target 116 participants
Start Date 2021-06-16
Est. Completion 2026-05-31
Phase Phase 2

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT04660760

The ClinicalTrials.gov registry entry for NCT04660760 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 116 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Academic and Community Cancer Research United, which has 21 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 10 conditions, with Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8 appearing as the primary indexed condition, and to 4 interventions — of which Quality-of-Life Assessment is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT04660760 reports 15 study locations spanning 12 distinct geographic areas — top geographies include Arizona, Florida, Wisconsin. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT04660760 about?

NCT04660760 is a clinical study titled "Ramucirumab and Trifluridine/Tipiracil or Paclitaxel for the Treatment of Patients With Previously Treated Advanced Gastric or Gastroesophageal Junction Cancer". This phase II trial studies the effect of the combination of ramucirumab and trifluridine/tipiracil or paclitaxel in treating patients with previously treated gastric or gastroesophageal junction cancer that has spread to other places in the body (advanced). Ramucirumab may damage tumor cells by tar...

What is the current status of trial NCT04660760?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 116 participants. The study started on 2021-06-16. Estimated completion is 2026-05-31.

What conditions does trial NCT04660760 study?

This clinical trial studies the following conditions: Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8, Clinical Stage IV Gastric Cancer AJCC v8, Clinical Stage III Gastric Cancer AJCC v8, Clinical Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8, Clinical Stage IVA Gastric Cancer AJCC v8. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT04660760?

The interventions under investigation include: Quality-of-Life Assessment (OTHER), Paclitaxel (DRUG), Ramucirumab (BIOLOGICAL), Trifluridine and Tipiracil Hydrochloride (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT04660760?

This trial is sponsored by Academic and Community Cancer Research United, which has 21 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT04660760 being conducted?

This trial has 15 study locations across Alabama, Arizona, California, Florida, Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial