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NCT04621175 · ClinicalTrials.gov registry record · NA
Effects of Essential Amino Acid-enriched Whey and Carbohydrate Co-ingestion on Protein Kinetics
A NA study of Energy Deficit, sponsored by United States Army Research Institute of Environmental Medicine.
- Completed
- Registry status
- NA
- Development phase
- 17
- Enrollment target
- 1
- Study location
NCT04621175: Completed NA study of Energy Deficit, sponsored by United States Army Research Institute of Environmental Medicine.
NCT04621175 is a NA study of Energy Deficit that has completed, run by United States Army Research Institute of Environmental Medicine. The registered enrollment target is 17 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04621175, a NA study of Energy Deficit, has completed, sponsored by United States Army Research Institute of Environmental Medicine.
- COMPLETED
- Registry status
- NA
- Development phase
- 17 participants
- Enrollment target
- 1
- Study location
Study Summary
Previous work conducted by the Investigators demonstrates that an essential amino acid(EAA)-enriched whey protein combination format is an efficient EAA/protein format to support enhanced whole-body protein balance and sustain muscle protein synthesis compared to isonitrogenous amounts of whey alone or a mixed-macronutrient meal. However, additional work is needed to optimize the formulation to ensure the best possible muscle and whole-body anabolic responses are achieved. This includes addressing the potential value of adding non-EAA/protein components to support energy demands. Providing additional non-protein energy to an EAA-enriched whey protein formulation may reduce the proportion of exogenous amino acids directed towards energy production thereby preserving its use for muscle protein synthesis. However, whether suppressing exogenous amino acid oxidation by providing additional carbohydrate allows for a greater muscle protein synthetic stimulus during moderate energy deficit (- 30% total energy requirements) is unknown. Therefore, this study will test the effects of EAA-enriched whey protein plus carbohydrate versus EAA-enriched whey plus additional EAA using a randomized, cross-sectional longitudinal study design.
Primary Outcome
Whole-body net balance will be determined using stable-isotope methodologies
Conditions Studied
Interventions
- DIETARY_SUPPLEMENT EAA+W & Carbohydrate
- DIETARY_SUPPLEMENT EAA+W & EAA
Study Locations (1)
Massachusetts
- US Army Research Institute of Environmental Medicine - Natick
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 17 participants |
| Start Date | 2020-09-09 |
| Est. Completion | 2022-08-23 |
| Phase | NA |
What the finished NCT04621175 record still lists
NCT04621175 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 17 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower).
The record links to 1 condition, with Energy Deficit appearing as the primary indexed condition, and to 2 interventions - of which EAA+W & Carbohydrate is the first listed.
NCT04621175 reports a single indexed study location in Massachusetts.
Frequently Asked Questions
What is clinical trial NCT04621175 about?
NCT04621175 is a clinical study titled "Effects of Essential Amino Acid-enriched Whey and Carbohydrate Co-ingestion on Protein Kinetics". Previous work conducted by the Investigators demonstrates that an essential amino acid(EAA)-enriched whey protein combination format is an efficient EAA/protein format to support enhanced whole-body protein balance and sustain muscle protein synthesis compared to isonitrogenous amounts of whey alone...
What is the current status of trial NCT04621175?
This trial is currently completed. It is a NA study. The enrollment target is 17 participants. The study started on 2020-09-09. Estimated completion is 2022-08-23.
What conditions does trial NCT04621175 study?
This clinical trial studies the following conditions: Energy Deficit.
What interventions are being tested in trial NCT04621175?
The interventions under investigation include: EAA+W & Carbohydrate (DIETARY_SUPPLEMENT), EAA+W & EAA (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT04621175?
This trial is sponsored by United States Army Research Institute of Environmental Medicine, which has 59 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04621175 being conducted?
This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04621175's enrollment target sits among peer trials
17 1871st of 2000 higher than 130 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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