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NCT04615572 · ClinicalTrials.gov registry record
Screening to Improve Survival in AL Amyloidosis
A clinical trial, sponsored by Tufts Medical Center.
- Completed
- Registry status
- 35
- Enrollment target
NCT04615572: Completed study, sponsored by Tufts Medical Center.
NCT04615572 is a clinical trial that has completed, run by Tufts Medical Center. The registered enrollment target is 35 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04615572 has completed, sponsored by Tufts Medical Center.
- COMPLETED
- Registry status
- 35 participants
- Enrollment target
Study Summary
The purpose of this study is to see whether certain genes may be linked with the development of AL amyloidosis in subjects 60 years of age or older with the blood disorders SMM and MGUS. A limited repertoire of immunoglobulin (Ig) variable region genes have been associated with AL amyloidosis. The clonal plasma cells of subjects with SMM and MGUS may express one of these Ig variable region genes indicating a risk of progression to AL amyloidosis and potentially enabling early diagnosis. We hope this study will help us begin to understand whether Ig variable region gene identification can be a useful tool for assessing a subject's risk of progression to AL amyloidosis.
Primary Outcome
By creating a multicenter network (N =6) we will have study centers in Massachusetts (1), California (2), New York (1), North Carolina (1) and Florida (1), enabling us to evaluate 50 patients 60 or older with λ SMM or λ MGUS and to determine based on gene identification whether their clonal λ IGVL genes are AL-related. This approach will identify undiagnosed patients early in the course of AL and patients at risk for AL.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 35 participants |
| Start Date | 2020-08-28 |
| Est. Completion | 2023-07-06 |
What the finished NCT04615572 record still lists
NCT04615572 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 35 participants, a relatively small participant target.
The record links to 0 conditions, and to 0 interventions.
NCT04615572 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04615572 about?
NCT04615572 is a clinical study titled "Screening to Improve Survival in AL Amyloidosis". The purpose of this study is to see whether certain genes may be linked with the development of AL amyloidosis in subjects 60 years of age or older with the blood disorders SMM and MGUS. A limited repertoire of immunoglobulin (Ig) variable region genes have been associated with AL amyloidosis. The c...
What is the current status of trial NCT04615572?
This trial is currently completed. The enrollment target is 35 participants. The study started on 2020-08-28. Estimated completion is 2023-07-06.
Who is sponsoring clinical trial NCT04615572?
This trial is sponsored by Tufts Medical Center, which has 169 total clinical trials registered on ClinicalTrials.gov.
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