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NCT04521972 · ClinicalTrials.gov registry record · NA
Impact of Room Light on Uterine Contractions and Labor Progression in Pregnancy
A NA study of Pregnancy Related and Labor; Poor, sponsored by Michigan State University.
- Recruiting
- Registry status
- NA
- Development phase
- 100
- Enrollment target
- 1
- Study location
NCT04521972: Recruiting NA study of Pregnancy Related and Labor; Poor, sponsored by Michigan State University.
NCT04521972 is a NA study of Pregnancy Related and Labor; Poor that is actively recruiting participants, run by Michigan State University. The registered enrollment target is 100 participants, below the 1,962-participant average among 99 other Pregnancy Related trials with a reported enrollment target (95% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04521972, a NA study of Pregnancy Related and Labor; Poor, is actively recruiting participants, sponsored by Michigan State University.
- RECRUITING
- Registry status
- NA
- Development phase
- 100 participants
- Enrollment target
- 1
- Study location
Study Summary
Today it remains a challenge to successfully both halt and induce labor progression. Induction of labor is a common obstetric intervention that 1 in 4 women will experience. The goal of induction of labor is to achieve a vaginal birth, however in almost 40% of first-time mothers it fails. Failed labor inductions require a caesarean delivery, which is associated with a vast range of adverse effects for both the mother and her baby. In this application we propose that a simple manipulation of room light will increase the success of vaginal birth through the use of optimal room light settings (halting labor=lights ON, promoting labor=reduced room light/red room light). A sparse literature has shown that the hormone melatonin might be an important hormone to consider during late pregnancy and labor. Pineal melatonin release is only released in darkness at night, where nocturnal light such as room light, suppress pineal melatonin release, reducing uterine contractions (Olcese et al 2013, https://pubmed.ncbi.nlm.nih.gov/22556015/, Rahman et al 2019, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453747/). Melatonin receptor become upregulated in the pregnant myometrium (uterine smooth muscle), and a small study in women having preterm birth, showed a high expression of melatonin receptor, at a gestational week where women not having preterm uterine contractions, had low levels of melatonin receptor, suggesting that premature increase in myometrium melatonin receptor might in some women be associated with preterm labor and birth (Olcese et al 2013, https://pubmed.ncbi.nlm.nih.gov/22556015/). This study will address how room light impacts melatonin release and uterine contractions in healthy pregnant women.
Primary Outcome
We will measure how room light during day and night periods impact uterine contractions during pregnancy and labor.
Conditions Studied
Interventions
- DEVICE Room light/light bulb
Study Locations (1)
Michigan
- Michigan State University - East Lansing
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 100 participants |
| Start Date | 2025-09-01 |
| Est. Completion | 2029-09-01 |
| Phase | NA |
What NCT04521972 shows while recruiting
NCT04521972 is an interventional study that assigns participants to a tested intervention. The registered 100 participants enrollment target is mid-sized for trials with a published cap, below the 1,962-participant average among 99 other Pregnancy Related trials with a reported enrollment target (95% lower).
The record links to 3 conditions, with Pregnancy Related appearing as the primary indexed condition, and to 1 intervention - of which Room light/light bulb is the first listed.
NCT04521972 reports a single indexed study location in Michigan.
Frequently Asked Questions
What is clinical trial NCT04521972 about?
NCT04521972 is a clinical study titled "Impact of Room Light on Uterine Contractions and Labor Progression in Pregnancy". Today it remains a challenge to successfully both halt and induce labor progression. Induction of labor is a common obstetric intervention that 1 in 4 women will experience. The goal of induction of labor is to achieve a vaginal birth, however in almost 40% of first-time mothers it fails. Failed lab...
What is the current status of trial NCT04521972?
This trial is currently recruiting. It is a NA study. The enrollment target is 100 participants. The study started on 2025-09-01. Estimated completion is 2029-09-01.
What conditions does trial NCT04521972 study?
This clinical trial studies the following conditions: Pregnancy Related, Labor; Poor, Uterine Contractions Weak.
What interventions are being tested in trial NCT04521972?
The interventions under investigation include: Room light/light bulb (DEVICE).
Who is sponsoring clinical trial NCT04521972?
This trial is sponsored by Michigan State University, which has 120 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04521972 being conducted?
This trial has 1 study location across Michigan. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Pregnancy Related
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04521972's enrollment target sits among peer trials
100 56th of 99 higher than 43 of 99 other Pregnancy Related trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Pregnancy Related trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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