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NCT04489797 · ClinicalTrials.gov registry record · Phase 1
A Study to Evaluate Effects of Proton-pump Inhibitor on Acalabrutinib Capsule When Administered Orally With COCA-COLA in Healthy Participants
A Phase 1 study, sponsored by AstraZeneca.
- Completed
- Registry status
- Phase 1
- Development phase
- 35
- Enrollment target
NCT04489797: Completed Phase 1 study, sponsored by AstraZeneca.
NCT04489797 is a Phase 1 study that has completed, run by AstraZeneca. The registered enrollment target is 35 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (42% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04489797, a Phase 1 study, has completed, sponsored by AstraZeneca.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 35 participants
- Enrollment target
Study Summary
This study is being conducted to support the clinical development of acalabrutinib in participants who need treatment with proton pump inhibitors while taking acalabrutinib.
Primary Outcome
Assessment of AUCinf for acalabrutinib and ACP-5862 (metabolite of acalabrutinib) following administration of capsule with and without rabeprazole.
Interventions
- DRUG Acalabrutinib
- DRUG Rabeprazole
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 35 participants |
| Start Date | 2020-07-20 |
| Est. Completion | 2020-08-28 |
| Phase | Phase 1 |
What the finished NCT04489797 record still lists
NCT04489797 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 35 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (42% lower).
The record links to 0 conditions, and to 2 interventions - of which Acalabrutinib is the first listed.
NCT04489797 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04489797 about?
NCT04489797 is a clinical study titled "A Study to Evaluate Effects of Proton-pump Inhibitor on Acalabrutinib Capsule When Administered Orally With COCA-COLA in Healthy Participants". This study is being conducted to support the clinical development of acalabrutinib in participants who need treatment with proton pump inhibitors while taking acalabrutinib.
What is the current status of trial NCT04489797?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 35 participants. The study started on 2020-07-20. Estimated completion is 2020-08-28.
What interventions are being tested in trial NCT04489797?
The interventions under investigation include: Acalabrutinib (DRUG), Rabeprazole (DRUG).
Who is sponsoring clinical trial NCT04489797?
This trial is sponsored by AstraZeneca, which has 1,285 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04489797's enrollment target sits among peer trials
35 1258th of 2000 higher than 728 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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