Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT04293341 · ClinicalTrials.gov registry record · NA
Comparing Individual Therapies for Veterans With Depression, PTSD, and Panic Disorder
A NA study, sponsored by VA Office of Research and Development.
- Completed
- Registry status
- NA
- Development phase
- 304
- Enrollment target
NCT04293341: Completed NA study, sponsored by VA Office of Research and Development.
NCT04293341 is a NA study that has completed, run by VA Office of Research and Development. The registered enrollment target is 304 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (78% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04293341, a NA study, has completed, sponsored by VA Office of Research and Development.
- COMPLETED
- Registry status
- NA
- Development phase
- 304 participants
- Enrollment target
Study Summary
Cognitive behavioral therapy (CBT) is a brief, efficient, and effective treatment for individuals with depressive/anxiety disorders. However, CBT is largely underutilized within the Department of Veterans Affairs due to the cost and burden of trainings necessary to deliver all of the related disorder-specific treatments (DSTs). Transdiagnostic Behavior Therapy (TBT), in contrast, is specifically designed to address numerous distinct disorders within a single protocol in Veterans with depressive/anxiety disorders, including posttraumatic stress disorder. The proposed research seeks to evaluate the efficacy of TBT by assessing psychiatric symptomatology and related impairment outcomes in Veterans with depressive/anxiety disorders via a randomized controlled trial of TBT and existing DSTs in Veterans with major depressive disorder, posttraumatic stress disorder, and panic disorder. Assessments will be completed at pre-, mid-, and post-treatment, and at 6-month follow-up. Process variables also will be investigated.
Primary Outcome
The PTSD Checklist for DSM-5 (PCL-5) is a 20-item self-report measure that assesses DSM-5 criteria PTSD symptoms. Items are scored on a 5-point scale, range from 0 (not at all) to 4 (extremely). The total scale score ranges from 0 to 80 with higher scores associated with more severe symptomatology. Previous versions of the PCL have been shown to have excellent internal consistency and excellent test-retest reliability in Veterans. In addition, the PCL-5 has been incorporated into standard assess
Interventions
- BEHAVIORAL Transdiagnostic Behavior Therapy
- BEHAVIORAL Cognitive Processing Therapy for PTSD
- BEHAVIORAL Cognitive Behavioral Therapy for MDD
- BEHAVIORAL Cognitive Behavioral Therapy for Panic Disorder
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 304 participants |
| Start Date | 2020-10-01 |
| Est. Completion | 2025-03-31 |
| Phase | NA |
What the finished NCT04293341 record still lists
NCT04293341 is an interventional study that assigns participants to a tested intervention. The registered 304 participants enrollment target is mid-sized for trials with a published cap, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (78% lower).
The record links to 0 conditions, and to 4 interventions - of which Transdiagnostic Behavior Therapy is the first listed.
NCT04293341 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04293341 about?
NCT04293341 is a clinical study titled "Comparing Individual Therapies for Veterans With Depression, PTSD, and Panic Disorder". Cognitive behavioral therapy (CBT) is a brief, efficient, and effective treatment for individuals with depressive/anxiety disorders. However, CBT is largely underutilized within the Department of Veterans Affairs due to the cost and burden of trainings necessary to deliver all of the related disorde...
What is the current status of trial NCT04293341?
This trial is currently completed. It is a NA study. The enrollment target is 304 participants. The study started on 2020-10-01. Estimated completion is 2025-03-31.
What interventions are being tested in trial NCT04293341?
The interventions under investigation include: Transdiagnostic Behavior Therapy (BEHAVIORAL), Cognitive Processing Therapy for PTSD (BEHAVIORAL), Cognitive Behavioral Therapy for MDD (BEHAVIORAL), Cognitive Behavioral Therapy for Panic Disorder (BEHAVIORAL).
Who is sponsoring clinical trial NCT04293341?
This trial is sponsored by VA Office of Research and Development, which has 1,668 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04293341's enrollment target sits among peer trials
304 327th of 2000 higher than 1,672 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT04750616 · 304 participants · Phase 2
NAD+ Augmentation in Cardiac Surgery Associated Myocardial Injury Trial
- NCT04994717 · 304 participants · Phase 3
Study Comparing Blinatumomab Alternating With Low-intensity Chemotherapy Versus Standard of Care Chemotherapy for Older Adults With Newly Diagnosed Philadelphia-negative B-cell Precursor Acute Lymphoblastic Leukemia
- NCT06036147 · 304 participants · NA
Concussion Health Improvement Program
- NCT06096844 · 304 participants · Phase 3
Chemotherapy Combined With Immunotherapy Versus Immunotherapy Alone for Older Adults With Stage IIIB-IV Lung Cancer, The ACHIEVE Trial
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI