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NCT04290546 · ClinicalTrials.gov registry record · Phase 1
CIML NK Cell in Head & Neck Cancer
A Phase 1 study, sponsored by Dana-Farber Cancer Institute.
- Completed
- Registry status
- Phase 1
- Development phase
- 11
- Enrollment target
NCT04290546: Completed Phase 1 study, sponsored by Dana-Farber Cancer Institute.
NCT04290546 is a Phase 1 study that has completed, run by Dana-Farber Cancer Institute. The registered enrollment target is 11 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (82% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04290546, a Phase 1 study, has completed, sponsored by Dana-Farber Cancer Institute.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 11 participants
- Enrollment target
Study Summary
This research study is evaluating the safety and efficacy of a combination drug and biologic therapy in patients with advanced head and neck cancer. This research study involves the following drugs and biologics: * CIML NK donor cells * IL-15 superagonist * Ipilimumab * Cetuximab
Primary Outcome
All patients receiving any dose of study treatment will be evaluated for safety. DLTs overall and by dose level will be reported as proportions with 90% exact binomial confidence intervals.
Interventions
- DRUG Ipilimumab
- DRUG Cetuximab
- DRUG Interleukin-15 Superagonist (N-803)
- BIOLOGICAL CIML NK cell Infusion
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 11 participants |
| Start Date | 2020-07-20 |
| Est. Completion | 2024-12-16 |
| Phase | Phase 1 |
What the finished NCT04290546 record still lists
NCT04290546 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 11 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (82% lower).
The record links to 0 conditions, and to 4 interventions - of which Ipilimumab is the first listed.
NCT04290546 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04290546 about?
NCT04290546 is a clinical study titled "CIML NK Cell in Head & Neck Cancer". This research study is evaluating the safety and efficacy of a combination drug and biologic therapy in patients with advanced head and neck cancer. This research study involves the following drugs and biologics: * CIML NK donor cells * IL-15 superagonist * Ipilimumab * Cetuximab
What is the current status of trial NCT04290546?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 11 participants. The study started on 2020-07-20. Estimated completion is 2024-12-16.
What interventions are being tested in trial NCT04290546?
The interventions under investigation include: Ipilimumab (DRUG), Cetuximab (DRUG), Interleukin-15 Superagonist (N-803) (DRUG), CIML NK cell Infusion (BIOLOGICAL).
Who is sponsoring clinical trial NCT04290546?
This trial is sponsored by Dana-Farber Cancer Institute, which has 781 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04290546's enrollment target sits among peer trials
11 1911th of 2000 higher than 88 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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