Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT04274179 · ClinicalTrials.gov registry record · Phase 3
Ketogenic Diet for New-Onset Absence Epilepsy
A Phase 3 study of Ketogenic Dieting and Epilepsy, Absence, sponsored by Johns Hopkins University.
- Recruiting
- Registry status
- Phase 3
- Development phase
- 40
- Enrollment target
- 1
- Study location
NCT04274179: Recruiting Phase 3 study of Ketogenic Dieting and Epilepsy, Absence, sponsored by Johns Hopkins University.
NCT04274179 is a Phase 3 study of Ketogenic Dieting and Epilepsy, Absence that is actively recruiting participants, run by Johns Hopkins University. The registered enrollment target is 40 participants, roughly in line with the 39-participant average among 5 other Ketogenic Dieting trials with a reported enrollment target. The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04274179, a Phase 3 study of Ketogenic Dieting and Epilepsy, Absence, is actively recruiting participants, sponsored by Johns Hopkins University.
- RECRUITING
- Registry status
- Phase 3
- Development phase
- 40 participants
- Enrollment target
- 1
- Study location
Study Summary
The ketogenic diet is a medical therapy for epilepsy that is used nearly predominantly for refractory epilepsy (after 2-3 drugs have been tried and failed). However, there is both published evidence for first-line use (infantile spasms, Glut1 deficiency syndrome) and also anecdotal experience (families choosing to change the child's (or the family' own) diet rather than use anticonvulsant medications). Childhood absence epilepsy (refractory) has been published as being responsive to ketogenic diet therapy by the investigators' group previously. This is a small, prospective, 3 month trial to assess if using a modified Atkins diet is a feasible and effective option for new-onset childhood absence epilepsy. The investigators will compare to a group of children in which the parents have declined and chose to start anticonvulsant medications.
Primary Outcome
Parental report of seizure frequency.
Conditions Studied
Interventions
- OTHER Modified Atkins Diet
- DRUG Absence epilepsy medications
Study Locations (1)
Maryland
- Johns Hopkins Hospital - Baltimore
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2020-08-10 |
| Est. Completion | 2026-05-01 |
| Phase | Phase 3 |
What NCT04274179 shows while recruiting
NCT04274179 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 40 participants, a relatively small participant target, roughly in line with the 39-participant average among 5 other Ketogenic Dieting trials with a reported enrollment target.
The record links to 3 conditions, with Ketogenic Dieting appearing as the primary indexed condition, and to 2 interventions - of which Modified Atkins Diet is the first listed.
NCT04274179 reports a single indexed study location in Maryland.
Frequently Asked Questions
What is clinical trial NCT04274179 about?
NCT04274179 is a clinical study titled "Ketogenic Diet for New-Onset Absence Epilepsy". The ketogenic diet is a medical therapy for epilepsy that is used nearly predominantly for refractory epilepsy (after 2-3 drugs have been tried and failed). However, there is both published evidence for first-line use (infantile spasms, Glut1 deficiency syndrome) and also anecdotal experience (famil...
What is the current status of trial NCT04274179?
This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 40 participants. The study started on 2020-08-10. Estimated completion is 2026-05-01.
What conditions does trial NCT04274179 study?
This clinical trial studies the following conditions: Ketogenic Dieting, Epilepsy, Absence, Absence Epilepsy.
What interventions are being tested in trial NCT04274179?
The interventions under investigation include: Modified Atkins Diet (OTHER), Absence epilepsy medications (DRUG).
Who is sponsoring clinical trial NCT04274179?
This trial is sponsored by Johns Hopkins University, which has 1,448 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04274179 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Ketogenic Dieting
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
-
Effect of Nutritional Ketosis on Alcohol Metabolism
RECRUITING · Phase 2
-
Ketogenic Diet and Diabetes Demonstration Project
RECRUITING · NA
-
Evaluation of Liver and Cardiometabolic Health Benefits on Low Carbohydrate Ketogenic Diet
COMPLETED
-
Determining the Ergogenic Effects of Carb10™ Supplementation on Carbohydrate-Rich and Carbohydrate-Restricted Diets
COMPLETED · NA
-
Impact of a Ketogenic Diet on Metabolic and Psychiatric Health in Patients With Bipolar or Schizophrenia Illness
COMPLETED · NA
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT01306019 · 40 participants · Phase 1
Lentiviral Gene Transfer for Treatment of Children Older Than Two Years of Age With X-Linked Severe Combined Immunodeficiency (XSCID)
- NCT01608152 · 40 participants
Development of a Video Game for the Improvement of Outcomes in Stem Cell Transplant Survivors
- NCT01668082 · 40 participants · NA
An Investigation of Brain Tumor Metabolism in Patients Undergoing Surgical Resection
- NCT02015013 · 40 participants · Phase 2
Hematopoietic Stem Cell Mobilization in Idiopathic CD4 Lymphocytopenia Patients and Healthy Controls for the Study of T Cell Maturation and Trafficking in Murine Models
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI