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NCT04269265 · ClinicalTrials.gov registry record · Phase 1
The Effect of Inflammation and Damage to Lymph Node Structures on Durable Protective Immunity Following Yellow Fever Vaccination
A Phase 1 study of Yellow Fever, sponsored by University of Minnesota.
- Completed
- Registry status
- Phase 1
- Development phase
- 43
- Enrollment target
- 2
- Study locations
NCT04269265 is a Phase 1 study of Yellow Fever that has completed, run by University of Minnesota. The registered enrollment target is 43 participants, below the 331-participant average among 3 other Yellow Fever trials with a reported enrollment target (87% lower). The trial reports 2 study locations across 2 states.
The verdict
NCT04269265, a Phase 1 study of Yellow Fever, has completed, sponsored by University of Minnesota.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 43 participants
- Enrollment target
- 2
- Study locations
Study Summary
Hypothesis: Infections other than HIV can cause LN inflammation and collagen damage to the fibroblastic reticular cell network (FRCn), which will lead to CD4 T cell depletion and impaired vaccine responses. This protocol will study yellow fever vaccine (YFV) in two cohorts of people, one from Uganda and the other from Minnesota where we collect lymphoid tissues (LT) and peripheral blood monocytes (PBMCs) before and after vaccination using a new technique to catalog infectious burden of the individual, determine the relationship between IA, Infections, and immune response.
Conditions Studied
Interventions
- BIOLOGICAL Yellow Fever Vaccine
Study Locations (2)
Minnesota
- University of Minnesota - Minneapolis
Other
- Joint Clinical Research Centre - Kampala
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 43 participants |
| Start Date | 2020-07-01 |
| Est. Completion | 2023-10-23 |
| Phase | Phase 1 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04269265
The ClinicalTrials.gov registry entry for NCT04269265 describes a study currently listed as completed, categorized as Phase 1. The registered enrollment target is 43 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 331-participant average among 3 other Yellow Fever trials with a reported enrollment target (87% lower). The listed sponsor is University of Minnesota, which has 966 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Yellow Fever appearing as the primary indexed condition, and to 1 intervention - of which Yellow Fever Vaccine is the first listed.
NCT04269265 reports 2 study locations spanning 2 distinct geographic areas - top geographies include Minnesota, Other.
Frequently Asked Questions
What is clinical trial NCT04269265 about?
NCT04269265 is a clinical study titled "The Effect of Inflammation and Damage to Lymph Node Structures on Durable Protective Immunity Following Yellow Fever Vaccination". Hypothesis: Infections other than HIV can cause LN inflammation and collagen damage to the fibroblastic reticular cell network (FRCn), which will lead to CD4 T cell depletion and impaired vaccine responses. This protocol will study yellow fever vaccine (YFV) in two cohorts of people, one from Uganda...
What is the current status of trial NCT04269265?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 43 participants. The study started on 2020-07-01. Estimated completion is 2023-10-23.
What conditions does trial NCT04269265 study?
This clinical trial studies the following conditions: Yellow Fever.
What interventions are being tested in trial NCT04269265?
The interventions under investigation include: Yellow Fever Vaccine (BIOLOGICAL).
Who is sponsoring clinical trial NCT04269265?
This trial is sponsored by University of Minnesota, which has 966 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04269265 being conducted?
This trial has 2 study locations across Minnesota. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Read our methodology - how this data is sourced, computed, and verified.
Related
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