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Durvalumab With or Without Olaparib as Maintenance Therapy After First-Line Treatment of Advanced and Recurrent Endometrial Cancer
NCT04269200 · View on ClinicalTrials.gov ↗
Study Summary
A study to assess the efficacy and safety of durvalumab in combination with platinum-based chemotherapy (paclitaxel + carboplatin) followed by maintenance durvalumab with or without olaparib for patients with newly diagnosed advanced or recurrent endometrial cancer.
Conditions Studied
Interventions
- DRUG Carboplatin
- DRUG olaparib
- BIOLOGICAL durvalumab
- DRUG durvalumab placebo
- DRUG olaparib placebo
Study Locations (20)
California
- Research Site — Concord
- Research Site — La Jolla
- Research Site — San Francisco
- Research Site — Santa Barbara
Florida
- Research Site — Fort Lauderdale
- Research Site — Tampa
Illinois
- Research Site — Arlington Heights
- Research Site — Chicago
Arizona
- Research Site — Tucson
Colorado
- Research Site — Aurora
Georgia
- Research Site — Savannah
Hawaii
- Research Site — Honolulu
Indiana
- Research Site — Indianapolis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 805 participants |
| Start Date | 2020-05-05 |
| Est. Completion | 2027-04-01 |
| Phase | Phase 3 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04269200
The ClinicalTrials.gov registry entry for NCT04269200 describes a study currently listed as active not recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 805 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is AstraZeneca, which has 1,053 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Endometrial Neoplasms appearing as the primary indexed condition, and to 5 interventions — of which Carboplatin is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT04269200 reports 20 study locations spanning 15 distinct geographic areas — top geographies include California, Florida, Illinois. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT04269200 about?
NCT04269200 is a clinical study titled "Durvalumab With or Without Olaparib as Maintenance Therapy After First-Line Treatment of Advanced and Recurrent Endometrial Cancer". A study to assess the efficacy and safety of durvalumab in combination with platinum-based chemotherapy (paclitaxel + carboplatin) followed by maintenance durvalumab with or without olaparib for patients with newly diagnosed advanced or recurrent endometrial cancer.
What is the current status of trial NCT04269200?
This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 805 participants. The study started on 2020-05-05. Estimated completion is 2027-04-01.
What conditions does trial NCT04269200 study?
This clinical trial studies the following conditions: Endometrial Neoplasms. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT04269200?
The interventions under investigation include: Carboplatin (DRUG), olaparib (DRUG), durvalumab (BIOLOGICAL), durvalumab placebo (DRUG), olaparib placebo (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT04269200?
This trial is sponsored by AstraZeneca, which has 1,053 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT04269200 being conducted?
This trial has 20 study locations across Arizona, California, Colorado, Florida, Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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