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NCT04265430 · ClinicalTrials.gov registry record · Phase 4
Serial Magnetic Resonance Imaging for the Prediction of Radiation-Induced Changes in Normal Tissue of Patients With Oral Cavity or Skull Base Tumors
A Phase 4 study of Osteoradionecrosis and Malignant Oral Cavity Neoplasm, sponsored by M.D. Anderson Cancer Center.
- Recruiting
- Registry status
- Phase 4
- Development phase
- 425
- Enrollment target
- 1
- Study location
NCT04265430: Recruiting Phase 4 study of Osteoradionecrosis and Malignant Oral Cavity Neoplasm, sponsored by M.D. Anderson Cancer Center.
NCT04265430 is a Phase 4 study of Osteoradionecrosis and Malignant Oral Cavity Neoplasm that is actively recruiting participants, run by M.D. Anderson Cancer Center. The registered enrollment target is 425 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (18% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04265430, a Phase 4 study of Osteoradionecrosis and Malignant Oral Cavity Neoplasm, is actively recruiting participants, sponsored by M.D. Anderson Cancer Center.
- RECRUITING
- Registry status
- Phase 4
- Development phase
- 425 participants
- Enrollment target
- 1
- Study location
Study Summary
This phase IV trial studies how well serial magnetic resonance imaging (MRI) after radiation therapy works in predicting radiation-induced changes in the normal tissue of patients with oral cavity or skull base tumors. Performing MRIs after radiation therapy for patients with oral cavity or skull base tumors may help to predict osteoradionecrosis (a change in non-cancerous tissue).
Primary Outcome
Will correlate whether post-therapy alterations in the observed multi-parametric imaging features can be used as surrogate bio-markers of normal tissue injury
Conditions Studied
Interventions
- OTHER Quality-of-Life Assessment
- PROCEDURE Magnetic Resonance Imaging
- OTHER Questionnaire Administration
- OTHER Contrast Agent
Study Locations (1)
Texas
- M D Anderson Cancer Center - Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 425 participants |
| Start Date | 2018-09-17 |
| Est. Completion | 2031-09-01 |
| Phase | Phase 4 |
What NCT04265430 shows while recruiting
NCT04265430 is an interventional study that assigns participants to a tested intervention. The registered 425 participants enrollment target is mid-sized for trials with a published cap, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (18% lower).
The record links to 3 conditions, with Osteoradionecrosis appearing as the primary indexed condition, and to 4 interventions - of which Quality-of-Life Assessment is the first listed.
NCT04265430 reports a single indexed study location in Texas.
Frequently Asked Questions
What is clinical trial NCT04265430 about?
NCT04265430 is a clinical study titled "Serial Magnetic Resonance Imaging for the Prediction of Radiation-Induced Changes in Normal Tissue of Patients With Oral Cavity or Skull Base Tumors". This phase IV trial studies how well serial magnetic resonance imaging (MRI) after radiation therapy works in predicting radiation-induced changes in the normal tissue of patients with oral cavity or skull base tumors. Performing MRIs after radiation therapy for patients with oral cavity or skull ba...
What is the current status of trial NCT04265430?
This trial is currently recruiting. It is a Phase 4 study. The enrollment target is 425 participants. The study started on 2018-09-17. Estimated completion is 2031-09-01.
What conditions does trial NCT04265430 study?
This clinical trial studies the following conditions: Osteoradionecrosis, Malignant Oral Cavity Neoplasm, Malignant Skull Base Neoplasm.
What interventions are being tested in trial NCT04265430?
The interventions under investigation include: Quality-of-Life Assessment (OTHER), Magnetic Resonance Imaging (PROCEDURE), Questionnaire Administration (OTHER), Contrast Agent (OTHER).
Who is sponsoring clinical trial NCT04265430?
This trial is sponsored by M.D. Anderson Cancer Center, which has 2,692 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04265430 being conducted?
This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Osteoradionecrosis
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04265430's enrollment target sits among peer trials
425 197th of 2000 higher than 1,803 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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