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NCT04198116 · ClinicalTrials.gov registry record · Phase 2
Combining Varenicline and Guanfacine for Smoking Cessation
A Phase 2 study, sponsored by Yale University.
- Completed
- Registry status
- Phase 2
- Development phase
- 167
- Enrollment target
NCT04198116: Completed Phase 2 study, sponsored by Yale University.
NCT04198116 is a Phase 2 study that has completed, run by Yale University. The registered enrollment target is 167 participants, above the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (26% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04198116, a Phase 2 study, has completed, sponsored by Yale University.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 167 participants
- Enrollment target
Study Summary
The novel design of this study combines a laboratory paradigm to evaluate stress-induced smoking behavior and smoking-related reinforcement, followed by a 12-week treatment phase to evaluate clinical outcomes.
Primary Outcome
Latency (in minutes) to time of first cigarette smoked during the 50-minute delay period.
Interventions
- DRUG Varenicline
- DRUG Guanfacine ER
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 167 participants |
| Start Date | 2020-11-01 |
| Est. Completion | 2025-04-30 |
| Phase | Phase 2 |
What the finished NCT04198116 record still lists
NCT04198116 is an interventional study that assigns participants to a tested intervention. The registered 167 participants enrollment target is mid-sized for trials with a published cap, above the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (26% higher).
The record links to 0 conditions, and to 2 interventions - of which Varenicline is the first listed.
NCT04198116 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04198116 about?
NCT04198116 is a clinical study titled "Combining Varenicline and Guanfacine for Smoking Cessation". The novel design of this study combines a laboratory paradigm to evaluate stress-induced smoking behavior and smoking-related reinforcement, followed by a 12-week treatment phase to evaluate clinical outcomes.
What is the current status of trial NCT04198116?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 167 participants. The study started on 2020-11-01. Estimated completion is 2025-04-30.
What interventions are being tested in trial NCT04198116?
The interventions under investigation include: Varenicline (DRUG), Guanfacine ER (DRUG).
Who is sponsoring clinical trial NCT04198116?
This trial is sponsored by Yale University, which has 1,492 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04198116's enrollment target sits among peer trials
167 406th of 2000 higher than 1,595 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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