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NCT04141020 · ClinicalTrials.gov registry record · Phase 2
Effect of Sirolimus on Molecular Alterations in Cerebral Aneurysms
A Phase 2 study of Cerebral Aneurysm, sponsored by University of Miami.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 80
- Enrollment target
- 1
- Study location
NCT04141020: Recruiting Phase 2 study of Cerebral Aneurysm, sponsored by University of Miami.
NCT04141020 is a Phase 2 study of Cerebral Aneurysm that is actively recruiting participants, run by University of Miami. The registered enrollment target is 80 participants, above the 50-participant average among 3 other Cerebral Aneurysm trials with a reported enrollment target (60% higher). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04141020, a Phase 2 study of Cerebral Aneurysm, is actively recruiting participants, sponsored by University of Miami.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 80 participants
- Enrollment target
- 1
- Study location
Study Summary
The objective of this study is to explore the effects of Sirolimus on the underlying molecular alterations of cerebral aneurysms.
Primary Outcome
Change in gene expressions will be reported as fold change from control arteries: superficial temporal artery from the same patient and the intracerebral temporal lobe artery from a different patient. Genes to be evaluated are endothelial cell marker genes such as Cluster of Differentiation (CD) 34, CD31, Von Willebrand Factor (vWF), E-selectin, Vascular Endothelial (VE)-cadherin and Endothelial Nitric Oxide Synthase (eNOS) and pro-inflammatory-matrix remodeling proliferation genes such as Matri
Conditions Studied
Interventions
- DRUG Sirolimus
- PROCEDURE Microsurgical clipping
- PROCEDURE Endovascular treatment
Study Locations (1)
Florida
- University of Miami - Miami
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 80 participants |
| Start Date | 2021-10-27 |
| Est. Completion | 2026-11-01 |
| Phase | Phase 2 |
What NCT04141020 shows while recruiting
NCT04141020 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 80 participants, a relatively small participant target, above the 50-participant average among 3 other Cerebral Aneurysm trials with a reported enrollment target (60% higher).
The record links to 1 condition, with Cerebral Aneurysm appearing as the primary indexed condition, and to 3 interventions - of which Sirolimus is the first listed.
NCT04141020 reports a single indexed study location in Florida.
Frequently Asked Questions
What is clinical trial NCT04141020 about?
NCT04141020 is a clinical study titled "Effect of Sirolimus on Molecular Alterations in Cerebral Aneurysms". The objective of this study is to explore the effects of Sirolimus on the underlying molecular alterations of cerebral aneurysms.
What is the current status of trial NCT04141020?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 80 participants. The study started on 2021-10-27. Estimated completion is 2026-11-01.
What conditions does trial NCT04141020 study?
This clinical trial studies the following conditions: Cerebral Aneurysm.
What interventions are being tested in trial NCT04141020?
The interventions under investigation include: Sirolimus (DRUG), Microsurgical clipping (PROCEDURE), Endovascular treatment (PROCEDURE).
Who is sponsoring clinical trial NCT04141020?
This trial is sponsored by University of Miami, which has 721 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04141020 being conducted?
This trial has 1 study location across Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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