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NCT04060966 · ClinicalTrials.gov registry record
Neural Mechanisms of Cost and Benefit Integration During Decision-Making, Aim 2: Acute & Lifetime Stress
A clinical trial of Healthy, sponsored by NYU Langone Health.
- Completed
- Registry status
- 397
- Enrollment target
- 1
- Study location
NCT04060966 is a study of Healthy that has completed, run by NYU Langone Health. The registered enrollment target is 397 participants, below the 647-participant average among 1,090 other Healthy trials with a reported enrollment target (39% lower). The trial reports 1 study location across 1 state.
The verdict
NCT04060966, a study of Healthy, has completed, sponsored by NYU Langone Health.
- COMPLETED
- Registry status
- 397 participants
- Enrollment target
- 1
- Study location
Study Summary
The central aim of this study is to characterize how the costs of acute and lifetime stress affect the neural architecture for decision-making in healthy humans. Investigators will use behavioral choice paradigms to measure how the costs of stress influence decisions about rewards (e.g., foods, money) as well as decisions about the use of self-control strategies. They will further examine associations between these stress measures and other decision variables commonly studied in our lab which have well-understood mechanisms, such as risk preferences. This behavioral work lays the foundation for an fMRI experiment that combines our measures of the behavioral costs of stress with neural measures of brain changes. Acute stress will be measured using a physiological stressor (cold-pressor task) coupled with saliva sample collection for cortisol analysis. Lifetime stress will be measured using a computerized life stress survey. We will study three cohorts: One purely behavioral cohort will be examined on-site (n=60). In a smaller subset of participants (n=40), investigators will measure neural activity changes in relevant brain areas as measured with MRI during decisions to use self-control in the presence of rewards. In a larger sample (n=500) the correlation between participants' risk preferences and lifetime stress exposure at scale using Amazon Mechanical Turk subjects will be measured.
Conditions Studied
Interventions
- DEVICE fMRI
- BEHAVIORAL Cold-Pressor Task (CPT)
- BEHAVIORAL Control CPT
Study Locations (1)
New York
- NYU Langone Health - New York
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 397 participants |
| Start Date | 2019-05-01 |
| Est. Completion | 2022-08-01 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04060966
The ClinicalTrials.gov registry entry for NCT04060966 describes a study currently listed as completed, categorized as an unspecified phase. The registered enrollment target is 397 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 647-participant average among 1,090 other Healthy trials with a reported enrollment target (39% lower). The listed sponsor is NYU Langone Health, which has 1,164 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Healthy appearing as the primary indexed condition, and to 3 interventions - of which fMRI is the first listed.
NCT04060966 reports 1 study location spanning 1 distinct geographic area - top geographies include New York.
Frequently Asked Questions
What is clinical trial NCT04060966 about?
NCT04060966 is a clinical study titled "Neural Mechanisms of Cost and Benefit Integration During Decision-Making, Aim 2: Acute & Lifetime Stress". The central aim of this study is to characterize how the costs of acute and lifetime stress affect the neural architecture for decision-making in healthy humans. Investigators will use behavioral choice paradigms to measure how the costs of stress influence decisions about rewards (e.g., foods, mone...
What is the current status of trial NCT04060966?
This trial is currently completed. The enrollment target is 397 participants. The study started on 2019-05-01. Estimated completion is 2022-08-01.
What conditions does trial NCT04060966 study?
This clinical trial studies the following conditions: Healthy.
What interventions are being tested in trial NCT04060966?
The interventions under investigation include: fMRI (DEVICE), Cold-Pressor Task (CPT) (BEHAVIORAL), Control CPT (BEHAVIORAL).
Who is sponsoring clinical trial NCT04060966?
This trial is sponsored by NYU Langone Health, which has 1,164 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04060966 being conducted?
This trial has 1 study location across New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Related
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