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NCT03985657 · ClinicalTrials.gov registry record · NA
Hemodynamics Response to Upper Airway Obstruction in Marfan Syndrome
A NA study, sponsored by Johns Hopkins University.
- Completed
- Registry status
- NA
- Development phase
- 31
- Enrollment target
NCT03985657: Completed NA study, sponsored by Johns Hopkins University.
NCT03985657 is a NA study that has completed, run by Johns Hopkins University. The registered enrollment target is 31 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03985657, a NA study, has completed, sponsored by Johns Hopkins University.
- COMPLETED
- Registry status
- NA
- Development phase
- 31 participants
- Enrollment target
Study Summary
Upper airway obstruction (UAO) is an unrecognized source of hemodynamic stress that may contribute to aortic adverse events in persons with Marfan Syndrome (MFS). UAO occurs during snoring and sleep apnea and is characterized by repetitive partial or complete obstruction of the upper airway during sleep. These obstructive breathing events lead to intermittent surges in blood pressure (BP) REF and large decreases in pleural pressure (Pes), thereby increasing the trans-mural aortic pressure (TMP) and imposing mechanical stress on the aorta during sleep. Although UAO is known to increase mechanical stress on the aorta, the magnitude of the increase is not known for persons with MFS. In this project, therefore, the investigators will also examine the changes in Pes and BP responses in periods of obstructed breathing and compare the diurnal markers or vascular stress between Baseline and CPAP studies in MFS persons.
Interventions
- DEVICE CPAP
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 31 participants |
| Start Date | 2018-06-06 |
| Est. Completion | 2019-12-06 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03985657
The ClinicalTrials.gov registry entry for NCT03985657 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 31 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Johns Hopkins University, which has 1,448 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which CPAP is the first listed.
NCT03985657 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT03985657 about?
NCT03985657 is a clinical study titled "Hemodynamics Response to Upper Airway Obstruction in Marfan Syndrome". Upper airway obstruction (UAO) is an unrecognized source of hemodynamic stress that may contribute to aortic adverse events in persons with Marfan Syndrome (MFS). UAO occurs during snoring and sleep apnea and is characterized by repetitive partial or complete obstruction of the upper airway during s...
What is the current status of trial NCT03985657?
This trial is currently completed. It is a NA study. The enrollment target is 31 participants. The study started on 2018-06-06. Estimated completion is 2019-12-06.
What interventions are being tested in trial NCT03985657?
The interventions under investigation include: CPAP (DEVICE).
Who is sponsoring clinical trial NCT03985657?
This trial is sponsored by Johns Hopkins University, which has 1,448 total clinical trials registered on ClinicalTrials.gov.
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