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NCT03985657 · ClinicalTrials.gov registry record · NA
Hemodynamics Response to Upper Airway Obstruction in Marfan Syndrome
A NA study, sponsored by Johns Hopkins University.
- Completed
- Registry status
- NA
- Development phase
- 31
- Enrollment target
NCT03985657: Completed NA study, sponsored by Johns Hopkins University.
NCT03985657 is a NA study that has completed, run by Johns Hopkins University. The registered enrollment target is 31 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03985657, a NA study, has completed, sponsored by Johns Hopkins University.
- COMPLETED
- Registry status
- NA
- Development phase
- 31 participants
- Enrollment target
Study Summary
Upper airway obstruction (UAO) is an unrecognized source of hemodynamic stress that may contribute to aortic adverse events in persons with Marfan Syndrome (MFS). UAO occurs during snoring and sleep apnea and is characterized by repetitive partial or complete obstruction of the upper airway during sleep. These obstructive breathing events lead to intermittent surges in blood pressure (BP) REF and large decreases in pleural pressure (Pes), thereby increasing the trans-mural aortic pressure (TMP) and imposing mechanical stress on the aorta during sleep. Although UAO is known to increase mechanical stress on the aorta, the magnitude of the increase is not known for persons with MFS. In this project, therefore, the investigators will also examine the changes in Pes and BP responses in periods of obstructed breathing and compare the diurnal markers or vascular stress between Baseline and CPAP studies in MFS persons.
Primary Outcome
Pleural pressure (Pes) in mmHg monitored using an esophageal catheter.
Interventions
- DEVICE CPAP
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 31 participants |
| Start Date | 2018-06-06 |
| Est. Completion | 2019-12-06 |
| Phase | NA |
What the finished NCT03985657 record still lists
NCT03985657 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 31 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower).
The record links to 0 conditions, and to 1 intervention - of which CPAP is the first listed.
NCT03985657 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03985657 about?
NCT03985657 is a clinical study titled "Hemodynamics Response to Upper Airway Obstruction in Marfan Syndrome". Upper airway obstruction (UAO) is an unrecognized source of hemodynamic stress that may contribute to aortic adverse events in persons with Marfan Syndrome (MFS). UAO occurs during snoring and sleep apnea and is characterized by repetitive partial or complete obstruction of the upper airway during s...
What is the current status of trial NCT03985657?
This trial is currently completed. It is a NA study. The enrollment target is 31 participants. The study started on 2018-06-06. Estimated completion is 2019-12-06.
What interventions are being tested in trial NCT03985657?
The interventions under investigation include: CPAP (DEVICE).
Who is sponsoring clinical trial NCT03985657?
This trial is sponsored by Johns Hopkins University, which has 1,448 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03985657's enrollment target sits among peer trials
31 1592nd of 2000 higher than 408 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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