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NCT03866278 · ClinicalTrials.gov registry record
Characterizing the Electroencephalogram Signature of Fentanyl During Induction of General Anesthesia
A clinical trial, sponsored by Massachusetts General Hospital.
- Completed
- Registry status
- 31
- Enrollment target
NCT03866278: Completed study, sponsored by Massachusetts General Hospital.
NCT03866278 is a clinical trial that has completed, run by Massachusetts General Hospital. The registered enrollment target is 31 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03866278 has completed, sponsored by Massachusetts General Hospital.
- COMPLETED
- Registry status
- 31 participants
- Enrollment target
Study Summary
While historically anesthesiologists rely on pharmacokinetics to track the loss of consciousness, new research in anesthesiology has identified the salient features of the electroencephalogram (EEG) that correlate to states of sedation and unconsciousness induced by different anesthetic drugs. While the EEG features of many sedative-hypnotic anesthetics have been well- characterized, the opioid analgesic drugs have not been analyzed in detail in this way. A characterization of the EEG signatures of opioid analgesic drugs could be useful in monitoring and titrating the effects of these drugs.
Primary Outcome
We estimated the fentanyl effect site concentration (ESC) in (nanograms/mL) using pharmacokinetic/pharmacodynamic (PK/PD) modeling implemented in StanpumpR. We estimated EEG power using multitaper spectral analysis and calculated the power in decibels (dB) within the theta band (4 - 8 Hz). To quantify the relationship between the EEG and fentanyl concentration, we constructed a linear mixed-effects model representing fentanyl concentration as a function of theta power.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 31 participants |
| Start Date | 2018-06-27 |
| Est. Completion | 2022-08-30 |
What the finished NCT03866278 record still lists
NCT03866278 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 31 participants, a relatively small participant target.
The record links to 0 conditions, and to 0 interventions.
NCT03866278 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03866278 about?
NCT03866278 is a clinical study titled "Characterizing the Electroencephalogram Signature of Fentanyl During Induction of General Anesthesia". While historically anesthesiologists rely on pharmacokinetics to track the loss of consciousness, new research in anesthesiology has identified the salient features of the electroencephalogram (EEG) that correlate to states of sedation and unconsciousness induced by different anesthetic drugs. While...
What is the current status of trial NCT03866278?
This trial is currently completed. The enrollment target is 31 participants. The study started on 2018-06-27. Estimated completion is 2022-08-30.
Who is sponsoring clinical trial NCT03866278?
This trial is sponsored by Massachusetts General Hospital, which has 2,032 total clinical trials registered on ClinicalTrials.gov.
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