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NCT03843359 · ClinicalTrials.gov registry record · Phase 1
A First Time in Human (FTIH) Study of GSK3745417 Administered to Participants With Advanced Solid Tumors
A Phase 1 study of Neoplasms, sponsored by GlaxoSmithKline.
- Active
- Registry status
- Phase 1
- Development phase
- 97
- Enrollment target
- 13
- Study locations
NCT03843359 is a Phase 1 study of Neoplasms that is active but no longer recruiting, run by GlaxoSmithKline. The registered enrollment target is 97 participants, below the 1,621-participant average among 158 other Neoplasms trials with a reported enrollment target (94% lower). The trial reports 13 study locations across 4 states.
The verdict
NCT03843359, a Phase 1 study of Neoplasms, is active but no longer recruiting, sponsored by GlaxoSmithKline.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 1
- Development phase
- 97 participants
- Enrollment target
- 13
- Study locations
Study Summary
This study aims to evaluate the safety, tolerability, and preliminary clinical activity and establish a recommended dose of GSK3745417 administered alone (Part 1A) or co-administered (Part 2A) with dostarlimab in participants with refractory/relapsed solid tumors. Both parts will consist of a dose escalation phase.
Conditions Studied
Interventions
- DRUG Dostarlimab
- DRUG GSK3745417
Study Locations (13)
Other
- GSK Investigational Site - Bordeaux
- GSK Investigational Site - Villejuif
- GSK Investigational Site - Tokyo
- GSK Investigational Site - Tokyo
- GSK Investigational Site - Amsterdam
- GSK Investigational Site - Amsterdam
- GSK Investigational Site - Seoul
- GSK Investigational Site - Barcelona
- GSK Investigational Site - Madrid
- GSK Investigational Site - Madrid
Texas
- GSK Investigational Site - Houston
Victoria
- GSK Investigational Site - Melbourne
Ontario
- GSK Investigational Site - Toronto
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 97 participants |
| Start Date | 2019-03-12 |
| Est. Completion | 2026-03-31 |
| Phase | Phase 1 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03843359
The ClinicalTrials.gov registry entry for NCT03843359 describes a study currently listed as active not recruiting, categorized as Phase 1. The registered enrollment target is 97 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 1,621-participant average among 158 other Neoplasms trials with a reported enrollment target (94% lower). The listed sponsor is GlaxoSmithKline, which has 1,345 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Neoplasms appearing as the primary indexed condition, and to 2 interventions - of which Dostarlimab is the first listed.
NCT03843359 reports 13 study locations spanning 4 distinct geographic areas - top geographies include Other, Texas, Victoria.
Frequently Asked Questions
What is clinical trial NCT03843359 about?
NCT03843359 is a clinical study titled "A First Time in Human (FTIH) Study of GSK3745417 Administered to Participants With Advanced Solid Tumors". This study aims to evaluate the safety, tolerability, and preliminary clinical activity and establish a recommended dose of GSK3745417 administered alone (Part 1A) or co-administered (Part 2A) with dostarlimab in participants with refractory/relapsed solid tumors. Both parts will consist of a dose e...
What is the current status of trial NCT03843359?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 97 participants. The study started on 2019-03-12. Estimated completion is 2026-03-31.
What conditions does trial NCT03843359 study?
This clinical trial studies the following conditions: Neoplasms.
What interventions are being tested in trial NCT03843359?
The interventions under investigation include: Dostarlimab (DRUG), GSK3745417 (DRUG).
Who is sponsoring clinical trial NCT03843359?
This trial is sponsored by GlaxoSmithKline, which has 1,345 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03843359 being conducted?
This trial has 13 study locations across Texas, Victoria, Ontario. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Related
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