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ACTIVE NOT RECRUITING Phase 1

APG-115 in Salivary Gland Cancer Trial

NCT03781986 · View on ClinicalTrials.gov ↗

Study Summary

This is a phase I/II trial to evaluate the efficacy of APG-115 +/- Carboplatin for the treatment p53 wild-type malignant salivary gland cancer. Part 1 consisted of 2 arms, arm A (APG-115 monotherapy) and arm B (APG-115 + Carboplatin) and was terminated early. Part 2 is a single arm study (APG-115 monotherapy).

Interventions

  • DRUG Carboplatin
  • DRUG APG-115

Study Locations (3)

Florida

  • Moffitt Cancer Center — Tampa

Illinois

  • University of Chicago — Chicago

Michigan

  • University of Michigan Rogel Cancer Center — Ann Arbor

Trial Details

FieldValue
Enrollment Target 41 participants
Start Date 2019-10-28
Est. Completion 2027-01
Phase Phase 1

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT03781986

The ClinicalTrials.gov registry entry for NCT03781986 describes a study currently listed as active not recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 41 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Michigan Rogel Cancer Center, which has 261 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Salivary Gland Cancer appearing as the primary indexed condition, and to 2 interventions — of which Carboplatin is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT03781986 reports 3 study locations spanning 3 distinct geographic areas — top geographies include Florida, Illinois, Michigan. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT03781986 about?

NCT03781986 is a clinical study titled "APG-115 in Salivary Gland Cancer Trial". This is a phase I/II trial to evaluate the efficacy of APG-115 +/- Carboplatin for the treatment p53 wild-type malignant salivary gland cancer. Part 1 consisted of 2 arms, arm A (APG-115 monotherapy) and arm B (APG-115 + Carboplatin) and was terminated early. Part 2 is a single arm study (APG-115 ...

What is the current status of trial NCT03781986?

This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 41 participants. The study started on 2019-10-28. Estimated completion is 2027-01.

What conditions does trial NCT03781986 study?

This clinical trial studies the following conditions: Salivary Gland Cancer, Malignant Salivary Gland Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT03781986?

The interventions under investigation include: Carboplatin (DRUG), APG-115 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT03781986?

This trial is sponsored by University of Michigan Rogel Cancer Center, which has 261 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT03781986 being conducted?

This trial has 3 study locations across Florida, Illinois, Michigan. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial