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NCT03650101 · ClinicalTrials.gov registry record
Improving Infant Hydrocephalus Outcomes in Uganda
A clinical trial of Hydrocephalus, sponsored by Boston Children's Hospital.
- Active
- Registry status
- 400
- Enrollment target
- 3
- Study locations
NCT03650101: Active study of Hydrocephalus, sponsored by Boston Children's Hospital.
NCT03650101 is a study of Hydrocephalus that is active but no longer recruiting, run by Boston Children's Hospital. The registered enrollment target is 400 participants, above the 110-participant average among 17 other Hydrocephalus trials with a reported enrollment target (264% higher). The trial reports 3 study locations across 3 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03650101, a study of Hydrocephalus, is active but no longer recruiting, sponsored by Boston Children's Hospital.
- ACTIVE NOT RECRUITING
- Registry status
- 400 participants
- Enrollment target
- 3
- Study locations
Study Summary
Neonatal postinfectious hydrocephalus (PIH) is a major public health problem in East Africa.The standard treatment has long been placement of a ventriculoperitoneal shunt (VPS) but these devices require life-long maintenance and nearly all fail multiple times. Endoscopic Third Ventriculostomy (ETV) with Choroid Plexus Cauterization (ETV/CPC) is an alternate treatment to give patients a shunt-free life. In this study, the investigators aim to optimize the metrics of evaluation as quantitative prognostic indicators of treatment response and long term outcomes.
Primary Outcome
Scores on the BSID-3, which is used to evaluate infants and toddlers 1 to 42 months of age, range from 1 to 19, with higher scores indicating better performance; the mean (±standard deviation(SD)) score in the general population is 10±3.
Conditions Studied
Interventions
- PROCEDURE ETV/CPC
Study Locations (3)
Pennsylvania
- Penn State University - University Park
Ontario
- The Hospital for Sick Children - Toronto
Other
- Cure Children's Hospital of Uganda - Mbale
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 400 participants |
| Start Date | 2021-05-05 |
| Est. Completion | 2027-12 |
What the registry record for NCT03650101 still lists
NCT03650101 is an observational study that tracks outcomes without assigning an intervention. The registered 400 participants enrollment target is mid-sized for trials with a published cap, above the 110-participant average among 17 other Hydrocephalus trials with a reported enrollment target (264% higher).
The record links to 1 condition, with Hydrocephalus appearing as the primary indexed condition, and to 1 intervention - of which ETV/CPC is the first listed.
NCT03650101 reports a single indexed study location in Pennsylvania, Ontario, Other.
Frequently Asked Questions
What is clinical trial NCT03650101 about?
NCT03650101 is a clinical study titled "Improving Infant Hydrocephalus Outcomes in Uganda". Neonatal postinfectious hydrocephalus (PIH) is a major public health problem in East Africa.The standard treatment has long been placement of a ventriculoperitoneal shunt (VPS) but these devices require life-long maintenance and nearly all fail multiple times. Endoscopic Third Ventriculostomy (ETV) ...
What is the current status of trial NCT03650101?
This trial is currently active not recruiting. The enrollment target is 400 participants. The study started on 2021-05-05. Estimated completion is 2027-12.
What conditions does trial NCT03650101 study?
This clinical trial studies the following conditions: Hydrocephalus.
What interventions are being tested in trial NCT03650101?
The interventions under investigation include: ETV/CPC (PROCEDURE).
Who is sponsoring clinical trial NCT03650101?
This trial is sponsored by Boston Children's Hospital, which has 462 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03650101 being conducted?
This trial has 3 study locations across Pennsylvania, Ontario. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Hydrocephalus
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT03650101's enrollment target sits among peer trials
400 2nd of 17 the highest of 17 other Hydrocephalus trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Hydrocephalus trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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Flow Detection in Open and Closed Shunt Valve Periods
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