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ClinicalTrials.gov 8 recruiting now official registry

High Risk Myelodysplastic Syndrome clinical trials

8 of 13 indexed High Risk Myelodysplastic Syndrome trials are currently recruiting.

13 US clinical trials · 8 currently recruiting

High Risk Myelodysplastic Syndrome is the subject of 13 registered US clinical trials on ClinicalTrials.gov, 8 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 13 in Phase 1-2 (earlier-stage). The most active sponsor is M.D. Anderson Cancer Center, running 9 of these trials.

The research picture

High Risk Myelodysplastic Syndrome has 13 registered US clinical trials, 8 of them open to new participants right now, about 62% of the total.

8
recruiting participants now
62%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
9
top sponsor: M.D. Anderson Cancer Center
Phase 18Phase 25

Active & Recent Trials

13 total, page 1 of 1

RECRUITING Phase 2 270 participants

Fludarabine Phosphate, Cytarabine, Filgrastim-sndz, Gemtuzumab Ozogamicin, and Idarubicin Hydrochloride in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome

M.D. Anderson Cancer Center

NCT00801489

RECRUITING Phase 1 116 participants

Venetoclax With Combination Chemotherapy in Treating Patients With Newly Diagnosed or Relapsed or Refractory Acute Myeloid Leukemia

M.D. Anderson Cancer Center

NCT03214562

RECRUITING Phase 2 100 participants

Dexrazoxane Hydrochloride in Preventing Heart-Related Side Effects of Chemotherapy in Participants With Blood Cancers

M.D. Anderson Cancer Center

NCT03589729

RECRUITING Phase 1 80 participants

Cladribine, Idarubicin, Cytarabine, and Quizartinib in Treating Patients With Newly Diagnosed, Relapsed, or Refractory Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome

M.D. Anderson Cancer Center

NCT04047641

RECRUITING Phase 1 72 participants

A Study of CBX-250 in Participants With Relapsed or Refractory Myeloid Leukemias

Crossbow Therapeutics

NCT06994676

RECRUITING Phase 1 58 participants

Edetate Calcium Disodium or Succimer in Treating Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome Undergoing Chemotherapy

M.D. Anderson Cancer Center

NCT03630991

RECRUITING Phase 1 52 participants

Liposomal Cytarabine and Daunorubicin (CPX-351) and Quizartinib for the Treatment of Acute Myeloid Leukemia and High Risk Myelodysplastic Syndrome

M.D. Anderson Cancer Center

NCT04128748

RECRUITING Phase 1 36 participants

Study of VIP943 in Subjects With Advanced CD123+ Hematologic Malignancies

Vincerx Pharma

NCT06034275

ACTIVE NOT RECRUITING Phase 2 204 participants

Busulfan, Fludarabine Phosphate, and Post-Transplant Cyclophosphamide in Treating Patients With Blood Cancer Undergoing Donor Stem Cell Transplant

M.D. Anderson Cancer Center

NCT02861417

ACTIVE NOT RECRUITING Phase 1 72 participants

Hu8F4 in Treating Patients With Advanced Hematologic Malignancies

M.D. Anderson Cancer Center

NCT02530034

ACTIVE NOT RECRUITING Phase 2 50 participants

Liposome-encapsulated Daunorubicin-Cytarabine and Gemtuzumab Ozogamicin in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia (AML) or High Risk Myelodysplastic Syndrome

M.D. Anderson Cancer Center

NCT03672539

ACTIVE NOT RECRUITING Phase 2 33 participants

Total Marrow and Lymphoid Irradiation as Conditioning Regimen Before Hematopoietic Cell Transplantation in Patients With Myelodysplastic Syndrome or Acute Leukemia

City of Hope Medical Center

NCT04262843

COMPLETED Phase 1 50 participants

Pomalidomide After Combination Chemotherapy in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome

National Cancer Institute (NCI)

NCT02029950

Phase Distribution

PhaseTrial count
Phase 1 8
Phase 2 5

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the High Risk Myelodysplastic Syndrome Trial Landscape

13 indexed High Risk Myelodysplastic Syndrome studies · 8 recruiting (62%).

Phase mix: 0 late (III/IV) vs 13 early (I/II).

Top sponsor: M.D. Anderson Cancer Center (9 trials), 4 others listed. 13 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for High Risk Myelodysplastic Syndrome?

PlainTrial tracks 13 US clinical trials for High Risk Myelodysplastic Syndrome, of which 8 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for High Risk Myelodysplastic Syndrome?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.