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NCT03574974 · ClinicalTrials.gov registry record · NA
Neurofeedback of Amygdala Activity for Post-traumatic Stress Disorder
A NA study, sponsored by Yale University.
- Terminated
- Registry status
- NA
- Development phase
- 27
- Enrollment target
NCT03574974: Clinical Trial NA study, sponsored by Yale University.
NCT03574974 is a NA study that was terminated before completion, run by Yale University. The registered enrollment target is 27 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03574974, a NA study, was terminated before completion, sponsored by Yale University.
- TERMINATED
- Registry status
- NA
- Development phase
- 27 participants
- Enrollment target
Study Summary
The primary purpose of this study is to investigate the efficacy of neurofeedback (NF) of real-time functional magnetic resonance imaging (rt-fMRI) data of the amygdala with regards to the reduction of post-traumatic stress disorder (PTSD) symptoms. A secondary purpose of this study is to use fMRI as a method of investigating brain function in individuals with PTSD. This study approach provides a tool for probing the neurobiology of PTSD by (1) testing the critical role of the amygdala in this disorder, and by (2) examining how amygdala connectivity is related to both amygdala regulation and clinical symptoms.
Primary Outcome
Control over the amygdala will be defined as the change in the blood-oxygen-level dependent (BOLD) signal in the target area (an individually-localized region of interest (ROI) in the amygdala) during down-regulation blocks following symptom provocation relative to rest. Investigators will assess the magnitude of change in control over the amygdala to trauma reminders from baseline to 30-day post treatment follow-up. This measure is based on beta values, which are unitless
Interventions
- DEVICE Experimental Feedback
- DEVICE Control Feedback
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 27 participants |
| Start Date | 2018-06-01 |
| Est. Completion | 2022-03-08 |
| Phase | NA |
Why NCT03574974 stopped before completion
NCT03574974 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 27 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower).
The record links to 0 conditions, and to 2 interventions - of which Experimental Feedback is the first listed.
NCT03574974 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03574974 about?
NCT03574974 is a clinical study titled "Neurofeedback of Amygdala Activity for Post-traumatic Stress Disorder". The primary purpose of this study is to investigate the efficacy of neurofeedback (NF) of real-time functional magnetic resonance imaging (rt-fMRI) data of the amygdala with regards to the reduction of post-traumatic stress disorder (PTSD) symptoms. A secondary purpose of this study is to use fMRI ...
What is the current status of trial NCT03574974?
This trial is currently terminated. It is a NA study. The enrollment target is 27 participants. The study started on 2018-06-01. Estimated completion is 2022-03-08.
What interventions are being tested in trial NCT03574974?
The interventions under investigation include: Experimental Feedback (DEVICE), Control Feedback (DEVICE).
Who is sponsoring clinical trial NCT03574974?
This trial is sponsored by Yale University, which has 1,492 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03574974's enrollment target sits among peer trials
27 1708th of 2000 higher than 291 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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