Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

ACTIVE NOT RECRUITING Phase 3

Nogapendekin Alfa Inbakicept for Advanced Non-Small Cell Lung Cancer

NCT03520686 · View on ClinicalTrials.gov ↗

Study Summary

This is a phase 3, open-label, 4-cohort study (3 randomized cohorts and 1 single-arm cohort). Participants enrolled in each cohort will be treated as detailed below. Each study cohort will be analyzed separately. Treatment will continue for up to 2 years, or until the patient experiences confirmed progressive disease or unacceptable toxicity, withdraws consent, or if the investigator feels that it is no longer in the patient's best interest to continue treatment. Patients will be followed for disease progression, post-therapies, and survival through 24 months after the first dose of study drug.

Conditions Studied

Interventions

  • DRUG Pembrolizumab
  • DRUG NAI + Pembrolizumab
  • DRUG NAI + Nivolumab + Ipilimumab
  • DRUG NAI + Pembrolizumab + Carboplatin + Nab-paclitaxel or Paclitaxel
  • DRUG Pembrolizumab + Carboplatin + Nab-paclitaxel or Paclitaxel (Investigator's choice)

Study Locations (20)

California

  • Chan Soon-Shiong Institute for Medicine — El Segundo
  • Adventist Health Glendale — Glendale
  • MemorialCare Health System — Long Beach
  • Adventist Health White Memorial — Los Angeles
  • Hoag Memorial Hospital — Newport Beach
  • Desert Hematology Oncology Medical Group — Rancho Mirage

Florida

  • Memorial Healthcare — Hollywood
  • Baptist Health South Florida - Miami Cancer Institute — Miami

Kentucky

  • Baptist Health - Lexington — Lexington
  • Baptist Health Louisville — Louisville

New York

  • University of Rochester — Rochester
  • Stony Brooke Medicine — Stony Brook

Alaska

  • Alaska Urological Institute - Alaska Clinical Research Center — Anchorage

Arkansas

  • Genesis Cancer Center — Hot Springs

Illinois

  • Healthcare Research Network — Tinley Park

Michigan

  • Karmanos Cancer Center — Detroit

Trial Details

FieldValue
Enrollment Target 1,538 participants
Start Date 2018-05-18
Est. Completion 2026-12-31
Phase Phase 3

Sponsor

ImmunityBio

48 total trials

Interested in This Trial?

Always speak with your doctor before enrolling in a clinical trial.

Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT03520686

The ClinicalTrials.gov registry entry for NCT03520686 describes a study currently listed as active not recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 1,538 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is ImmunityBio, which has 48 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Non Small Cell Lung Cancer appearing as the primary indexed condition, and to 5 interventions — of which Pembrolizumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT03520686 reports 20 study locations spanning 12 distinct geographic areas — top geographies include California, Florida, Kentucky. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT03520686 about?

NCT03520686 is a clinical study titled "Nogapendekin Alfa Inbakicept for Advanced Non-Small Cell Lung Cancer". This is a phase 3, open-label, 4-cohort study (3 randomized cohorts and 1 single-arm cohort). Participants enrolled in each cohort will be treated as detailed below. Each study cohort will be analyzed separately. Treatment will continue for up to 2 years, or until the patient experiences confirmed p...

What is the current status of trial NCT03520686?

This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 1,538 participants. The study started on 2018-05-18. Estimated completion is 2026-12-31.

What conditions does trial NCT03520686 study?

This clinical trial studies the following conditions: Non Small Cell Lung Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT03520686?

The interventions under investigation include: Pembrolizumab (DRUG), NAI + Pembrolizumab (DRUG), NAI + Nivolumab + Ipilimumab (DRUG), NAI + Pembrolizumab + Carboplatin + Nab-paclitaxel or Paclitaxel (DRUG), Pembrolizumab + Carboplatin + Nab-paclitaxel or Paclitaxel (Investigator's choice) (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT03520686?

This trial is sponsored by ImmunityBio, which has 48 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT03520686 being conducted?

This trial has 20 study locations across Alaska, Arkansas, California, Florida, Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial