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NCT03451409 · ClinicalTrials.gov registry record
Neurobiology of Sensory Phenomena in Obsessive-Compulsive Disorder
A clinical trial, sponsored by NYU Langone Health.
- Completed
- Registry status
- 308
- Enrollment target
NCT03451409: Completed study, sponsored by NYU Langone Health.
NCT03451409 is a clinical trial that has completed, run by NYU Langone Health. The registered enrollment target is 308 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03451409 has completed, sponsored by NYU Langone Health.
- COMPLETED
- Registry status
- 308 participants
- Enrollment target
Study Summary
The Research Domain Criteria (RDoC) approach seeks to address the neurobiological mechanisms of sensory symptoms in patients with obsessive-compulsive disorder (OCD) by investigating dimensional components of behavior that more closely align with brain circuitry. This project focuses on the dimensional symptom of sensory phenomena (SP), which are uncomfortable or aversive sensory experiences that drive repetitive behaviors in OCD, including "not just right" sensations, physical urges, and sensations of disgust. SP are very prevalent, occurring in 60-80% of OCD patients, and experienced as highly distressing. Unfortunately, SP are not well addressed by standard treatment approaches, which may be in part because their neurobiological mechanisms are not well understood. This project builds on our preliminary data to (1) investigate the neural mechanisms of SP in large OCD cohort showing the full range of SP severity and (2) probe for familial risk markers in unaffected siblings of patients. For Aim 1, SP will be measured in 100 OCD patients using the Sensory Phenomena Scale. Diffusion and fMRI data will be acquired during rest and fMRI tasks. In order to identify familial risk markers, Aim 2 will compare sensory phenomena and neural circuitry between OCD probands, 50 unaffected biological siblings of OCD patients, and 50 unrelated healthy controls without a family history of Axis 1 disorders.
Primary Outcome
Statistical modeling using path analysis will test whether brain activation, functional connectivity, and diffusion measures predict Sensory Phenomena (SP) better than alternative models of predictive influence.
Interventions
- OTHER Tasked based functional MRI (fMRI)
- OTHER Eye Tracking Device
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 308 participants |
| Start Date | 2018-05-05 |
| Est. Completion | 2024-01-24 |
What the finished NCT03451409 record still lists
NCT03451409 is an observational study that tracks outcomes without assigning an intervention. The registered 308 participants enrollment target is mid-sized for trials with a published cap.
The record links to 0 conditions, and to 2 interventions - of which Tasked based functional MRI (fMRI) is the first listed.
NCT03451409 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03451409 about?
NCT03451409 is a clinical study titled "Neurobiology of Sensory Phenomena in Obsessive-Compulsive Disorder". The Research Domain Criteria (RDoC) approach seeks to address the neurobiological mechanisms of sensory symptoms in patients with obsessive-compulsive disorder (OCD) by investigating dimensional components of behavior that more closely align with brain circuitry. This project focuses on the dimensio...
What is the current status of trial NCT03451409?
This trial is currently completed. The enrollment target is 308 participants. The study started on 2018-05-05. Estimated completion is 2024-01-24.
What interventions are being tested in trial NCT03451409?
The interventions under investigation include: Tasked based functional MRI (fMRI) (OTHER), Eye Tracking Device (OTHER).
Who is sponsoring clinical trial NCT03451409?
This trial is sponsored by NYU Langone Health, which has 1,164 total clinical trials registered on ClinicalTrials.gov.
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