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NCT03329950 · ClinicalTrials.gov registry record · Phase 1
A Study of CDX-1140 (CD40) as Monotherapy or in Combination in Patients With Advanced Malignancies
A Phase 1 study, sponsored by Celldex Therapeutics.
- Completed
- Registry status
- Phase 1
- Development phase
- 132
- Enrollment target
NCT03329950: Completed Phase 1 study, sponsored by Celldex Therapeutics.
NCT03329950 is a Phase 1 study that has completed, run by Celldex Therapeutics. The registered enrollment target is 132 participants, above the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (120% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03329950, a Phase 1 study, has completed, sponsored by Celldex Therapeutics.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 132 participants
- Enrollment target
Study Summary
This is a study to determine the maximum tolerated dose (MTD) for CDX-1140 (CD40 antibody), either alone or in combination with CDX-301 (FLT3L), pembrolizumab, or chemotherapy and to further evaluate its tolerability and efficacy in expansion cohorts once the MTD is determined.
Primary Outcome
The rates of drug-related adverse events will be summarized and maximum tolerated dose will be determined.
Interventions
- DRUG pembrolizumab
- DRUG Chemotherapy
- DRUG CDX-1140
- DRUG CDX-301
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 132 participants |
| Start Date | 2017-12-01 |
| Est. Completion | 2022-09-13 |
| Phase | Phase 1 |
What the finished NCT03329950 record still lists
NCT03329950 is an interventional study that assigns participants to a tested intervention. The registered 132 participants enrollment target is mid-sized for trials with a published cap, above the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (120% higher).
The record links to 0 conditions, and to 4 interventions - of which pembrolizumab is the first listed.
NCT03329950 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03329950 about?
NCT03329950 is a clinical study titled "A Study of CDX-1140 (CD40) as Monotherapy or in Combination in Patients With Advanced Malignancies". This is a study to determine the maximum tolerated dose (MTD) for CDX-1140 (CD40 antibody), either alone or in combination with CDX-301 (FLT3L), pembrolizumab, or chemotherapy and to further evaluate its tolerability and efficacy in expansion cohorts once the MTD is determined.
What is the current status of trial NCT03329950?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 132 participants. The study started on 2017-12-01. Estimated completion is 2022-09-13.
What interventions are being tested in trial NCT03329950?
The interventions under investigation include: pembrolizumab (DRUG), Chemotherapy (DRUG), CDX-1140 (DRUG), CDX-301 (DRUG).
Who is sponsoring clinical trial NCT03329950?
This trial is sponsored by Celldex Therapeutics, which has 42 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03329950's enrollment target sits among peer trials
132 432nd of 2000 higher than 1,562 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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