Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT03302741 · ClinicalTrials.gov registry record · Phase 4
Imaging of 3D Innervation Zone Distribution in Spastic Muscles From High-density Surface EMG Recordings
A Phase 4 study of Spasticity, sponsored by The University of Texas Health Science Center, Houston.
- Completed
- Registry status
- Phase 4
- Development phase
- 17
- Enrollment target
- 1
- Study location
NCT03302741: Completed Phase 4 study of Spasticity, sponsored by The University of Texas Health Science Center, Houston.
NCT03302741 is a Phase 4 study of Spasticity that has completed, run by The University of Texas Health Science Center, Houston. The registered enrollment target is 17 participants, below the 90-participant average among 8 other Spasticity trials with a reported enrollment target (81% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03302741, a Phase 4 study of Spasticity, has completed, sponsored by The University of Texas Health Science Center, Houston.
- COMPLETED
- Registry status
- Phase 4
- Development phase
- 17 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of this study is to evaluate if it is possible to use a new 3D imaging method to guide Botulinum neurotoxin (BTX) injection for muscle spasticity management after stroke. This imaging method is called three dimensional innervation zone imaging, or 3DIZI.
Primary Outcome
Each subject will receive a total of 60 degrees of computer-controlled elbow extension stretching at different speeds. The stretch ends at 10 degrees beyond the resting angle of the elbow joint during standing to offset the baseline difference among subjects. From the angle-torque relations, reflex torque is obtained after subtracting passive torque at 5˚/sec from those at 50˚/sec or 100˚/sec. Reflex torque is considered to reflect the neural component of muscle spasticity.
Conditions Studied
Interventions
- OTHER Physical Therapy
- DRUG Botulinum neurotoxin (BTX)
- DEVICE Standard BTX injection (ultrasound guided)
- DEVICE 3-dimensional innervation zone (3DIZ) guided injection
Study Locations (1)
Texas
- The University of Texas Health Science Center at Houston - Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 17 participants |
| Start Date | 2017-11-21 |
| Est. Completion | 2019-11-18 |
| Phase | Phase 4 |
What the finished NCT03302741 record still lists
NCT03302741 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 17 participants, a relatively small participant target, below the 90-participant average among 8 other Spasticity trials with a reported enrollment target (81% lower).
The record links to 1 condition, with Spasticity appearing as the primary indexed condition, and to 4 interventions - of which Physical Therapy is the first listed.
NCT03302741 reports a single indexed study location in Texas.
Frequently Asked Questions
What is clinical trial NCT03302741 about?
NCT03302741 is a clinical study titled "Imaging of 3D Innervation Zone Distribution in Spastic Muscles From High-density Surface EMG Recordings". The purpose of this study is to evaluate if it is possible to use a new 3D imaging method to guide Botulinum neurotoxin (BTX) injection for muscle spasticity management after stroke. This imaging method is called three dimensional innervation zone imaging, or 3DIZI.
What is the current status of trial NCT03302741?
This trial is currently completed. It is a Phase 4 study. The enrollment target is 17 participants. The study started on 2017-11-21. Estimated completion is 2019-11-18.
What conditions does trial NCT03302741 study?
This clinical trial studies the following conditions: Spasticity.
What interventions are being tested in trial NCT03302741?
The interventions under investigation include: Physical Therapy (OTHER), Botulinum neurotoxin (BTX) (DRUG), Standard BTX injection (ultrasound guided) (DEVICE), 3-dimensional innervation zone (3DIZ) guided injection (DEVICE).
Who is sponsoring clinical trial NCT03302741?
This trial is sponsored by The University of Texas Health Science Center, Houston, which has 732 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03302741 being conducted?
This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Spasticity
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT03302741's enrollment target sits among peer trials
17 8th of 8 higher than 1 of 8 other Spasticity trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Spasticity trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Comparative Efficacy of Three Preparations of Botox-A in Treating Spasticity
COMPLETED · Phase 4
-
A Study to Assess the Safety and Efficacy of IPN10200 in Adult Participants With Upper Limb Spasticity.
RECRUITING · Phase 1
-
Dry Needling in Multiple Sclerosis
RECRUITING · NA
-
Leg Stretching Using an Exoskeleton on Demand for People With Spasticity
RECRUITING · NA
-
Spinal Cord Stimulation to Augment Activity Based Therapy
COMPLETED · NA
-
Compare Two Guidance Techniques for Botulinum Toxin Injections for the Treatment of Limb Spasticity and Focal Dystonia
COMPLETED · NA
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT02090140 · 17 participants · NA
Microfracture Versus Adipose Derived Stem Cells for the Treatment of Articular Cartilage Defects
- NCT03317860 · 17 participants · NA
Improving Measurement and Treatment of Post-stroke Neglect
- NCT04356469 · 17 participants · Phase 2
TCR Alpha Beta T-cell Depleted Haploidentical HCT in the Treatment of Non-Malignant Hematological Disorders in Children
- NCT04414046 · 17 participants · Phase 2
TCR Alpha Beta T-cell Depleted Haploidentical HCT in the Treatment of Primary Immunodeficiency and Inherited Metabolic Disorders in Children
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI