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NCT03301740 · ClinicalTrials.gov registry record · NA
Ultrafiltration Profiling and Outcomes Among Individuals on Maintenance Hemodialysis
A NA study, sponsored by University of North Carolina, Chapel Hill.
- Completed
- Registry status
- NA
- Development phase
- 34
- Enrollment target
NCT03301740: Completed NA study, sponsored by University of North Carolina, Chapel Hill.
NCT03301740 is a NA study that has completed, run by University of North Carolina, Chapel Hill. The registered enrollment target is 34 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03301740, a NA study, has completed, sponsored by University of North Carolina, Chapel Hill.
- COMPLETED
- Registry status
- NA
- Development phase
- 34 participants
- Enrollment target
Study Summary
The rate of fluid removal (ultrafiltration, UF) during hemodialysis (HD) may contribute to cardiovascular morbidity and mortality among individuals receiving maintenance HD. More rapid UF rates are associated with higher morbidity and mortality. Ultrafiltration profiling, the practice of varying UF rates to maximize fluid removal during periods of greatest hydration and plasma oncotic pressures, is one treatment modification that may reduce UF-related harm without necessitating reduction in interdialytic fluid intake or longer HD treatments. To date, UF profiling has not been adequately studied independent of sodium profiling. This study investigates the comparative effect of UF profiling versus non-profiled conventional HD on select cardiovascular and patient-reported outcomes. Participants will complete two phases of UF profiling and two phases of conventional HD and will act as their own controls.
Primary Outcome
Intradialytic blood pressure (BP) was measured with an upper extremity cuff in seated position at 15-minute intervals during each hemodialysis treatment per standard dialysis clinic protocols. Intradialytic hypotension was defined as the presence of a nadir systolic BP \<90 mmHg. Odds ratios were estimated using a mixed model (repeated measures logistic regression model).
Interventions
- OTHER UF profiling during HD
- OTHER Conventional HD
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 34 participants |
| Start Date | 2018-03-12 |
| Est. Completion | 2018-12-18 |
| Phase | NA |
What the finished NCT03301740 record still lists
NCT03301740 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 34 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower).
The record links to 0 conditions, and to 2 interventions - of which UF profiling during HD is the first listed.
NCT03301740 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03301740 about?
NCT03301740 is a clinical study titled "Ultrafiltration Profiling and Outcomes Among Individuals on Maintenance Hemodialysis". The rate of fluid removal (ultrafiltration, UF) during hemodialysis (HD) may contribute to cardiovascular morbidity and mortality among individuals receiving maintenance HD. More rapid UF rates are associated with higher morbidity and mortality. Ultrafiltration profiling, the practice of varying UF ...
What is the current status of trial NCT03301740?
This trial is currently completed. It is a NA study. The enrollment target is 34 participants. The study started on 2018-03-12. Estimated completion is 2018-12-18.
What interventions are being tested in trial NCT03301740?
The interventions under investigation include: UF profiling during HD (OTHER), Conventional HD (OTHER).
Who is sponsoring clinical trial NCT03301740?
This trial is sponsored by University of North Carolina, Chapel Hill, which has 1,109 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03301740's enrollment target sits among peer trials
34 1570th of 2000 higher than 427 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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