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NCT03088826 · ClinicalTrials.gov registry record · Phase 2
Analgesic Efficacy of (MSIR)/Acetaminophen vs. Oxycodone/Acetaminophen (Percocet)
A Phase 2 study, sponsored by Antonios Likourezos.
- Completed
- Registry status
- Phase 2
- Development phase
- 80
- Enrollment target
NCT03088826: Completed Phase 2 study, sponsored by Antonios Likourezos.
NCT03088826 is a Phase 2 study that has completed, run by Antonios Likourezos. The registered enrollment target is 80 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (40% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03088826, a Phase 2 study, has completed, sponsored by Antonios Likourezos.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 80 participants
- Enrollment target
Study Summary
Oxycodone and Hydrocodone are the most commonly used oral opioid analgesics in the emergency department and in outpatient settings. Both medications have a very high potential for abuse due to the prominence of the euphoric effect (abuse liability) and relative lack of "bad "or "negative" effects (likeability). The highly addictive properties of these medications lead to recurrent ED visits for repetitive dosing and prescribing that may lead to abuse, misuse, development of dependence and addiction, and, most importantly, death due to overdose. In contrast, several research papers demonstrated that administration of MSIR results in similar analgesic efficacy to Oxycodone and Hydrocodone but with significantly less euphoric and rewarding associated effects. In addition, consumption of large doses of MSIR leads to dysphoria, vomiting and sedation ("negative effects"). To the investigators' knowledge, there are no randomized controlled trials in the ED that directly compared analgesic efficacy of MSIR to Percocet
Primary Outcome
The reduction of pain at 60 minutes from baseline: The pain scale ranges from 0 to 10 with 0 being no pain, 5 being moderate pain and 10 being very severe pain.
Interventions
- DRUG Acetaminophen
- DRUG Oxycodone
- DRUG Morphine Sulfate
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 80 participants |
| Start Date | 2017-08-18 |
| Est. Completion | 2020-12-22 |
| Phase | Phase 2 |
What the finished NCT03088826 record still lists
NCT03088826 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 80 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (40% lower).
The record links to 0 conditions, and to 3 interventions - of which Acetaminophen is the first listed.
NCT03088826 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03088826 about?
NCT03088826 is a clinical study titled "Analgesic Efficacy of (MSIR)/Acetaminophen vs. Oxycodone/Acetaminophen (Percocet)". Oxycodone and Hydrocodone are the most commonly used oral opioid analgesics in the emergency department and in outpatient settings. Both medications have a very high potential for abuse due to the prominence of the euphoric effect (abuse liability) and relative lack of "bad "or "negative" effects (l...
What is the current status of trial NCT03088826?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 80 participants. The study started on 2017-08-18. Estimated completion is 2020-12-22.
What interventions are being tested in trial NCT03088826?
The interventions under investigation include: Acetaminophen (DRUG), Oxycodone (DRUG), Morphine Sulfate (DRUG).
Who is sponsoring clinical trial NCT03088826?
This trial is sponsored by Antonios Likourezos, which has 33 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03088826's enrollment target sits among peer trials
80 842nd of 2000 higher than 1,117 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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