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NCT02908308 · ClinicalTrials.gov registry record · NA
Targeted Hypothermia Versus Targeted Normothermia After Out-of-hospital Cardiac Arrest
A NA study of Out-Of-Hospital Cardiac Arrest, sponsored by Helsingborgs Hospital.
- Completed
- Registry status
- NA
- Development phase
- 1,900
- Enrollment target
- 20
- Study locations
NCT02908308: Completed NA study of Out-Of-Hospital Cardiac Arrest, sponsored by Helsingborgs Hospital.
NCT02908308 is a NA study of Out-Of-Hospital Cardiac Arrest that has completed, run by Helsingborgs Hospital. The registered enrollment target is 1,900 participants, above the 1,168-participant average among 4 other Out-Of-Hospital Cardiac Arrest trials with a reported enrollment target (63% higher). The trial reports 20 study locations across 6 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02908308, a NA study of Out-Of-Hospital Cardiac Arrest, has completed, sponsored by Helsingborgs Hospital.
- COMPLETED
- Registry status
- NA
- Development phase
- 1,900 participants
- Enrollment target
- 20
- Study locations
Study Summary
ILCOR guidelines recommend Target Temperature Management (TTM) to between 32°C and 36°C after out-of-hospital cardiac arrest, based on low quality evidence. In a previous trial, TTM at 33°C did not confer a survival benefit or improved neurological function, compared to TTM at 36°C. A lower target temperature might be beneficial compared with normothermia and early treatment of fever. Therefore the primary purpose of the TTM2-trial will be to study any differences in mortality, neurological function and quality of life between a target temperature of 33°C and standard care avoiding fever.
Primary Outcome
Landmark mortality at 180 days
Conditions Studied
Interventions
- PROCEDURE Targeted temperature management to 33°C
- PROCEDURE Standard care with early treatment of fever
Study Locations (20)
Other
- Austin Hospital - Melbourne
- Nepean Hospital - Sydney
- Royal North Shore Hospital - Sydney
- Innsbruck University Hospital - Innsbruck
- Erasme Hospital - Brussels
- Ziekenhuis Oost-Limburg - Genk
- Hradec Kralove Hospital - Hradec Králové
- Liberec Hospital - Liberec
- General University Hospital - Prague
- Aarhus University Hospital - Aarhus
- Chu Dupuytren - Limoges
New South Wales
- John Hunter Hospital - Newcastle
- Concord Repatriation General Hospital - Sydney
- Liverpool Hospital - Sydney
- St Vincent's Hospital - Sydney
Victoria
- Northern Hospital - Epping
- The Alfred - Melbourne
New York
- Mayo Clinic Hospital-St. Mary's Campus - Rochester
Pennsylvania
- UPMC-Presbyterian - Pittsburgh
Queensland
- Princess Alexandra Hospital - Brisbane
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,900 participants |
| Start Date | 2017-11-18 |
| Est. Completion | 2022-12-31 |
| Phase | NA |
What the finished NCT02908308 record still lists
NCT02908308 is an interventional study that assigns participants to a tested intervention. Its 1,900 participants enrollment target places it among the larger protocols in the corpus, above the 1,168-participant average among 4 other Out-Of-Hospital Cardiac Arrest trials with a reported enrollment target (63% higher).
The record links to 1 condition, with Out-Of-Hospital Cardiac Arrest appearing as the primary indexed condition, and to 2 interventions - of which Targeted temperature management to 33°C is the first listed.
NCT02908308 names 20 study sites across 6 states, led by Other, New South Wales, Victoria.
Frequently Asked Questions
What is clinical trial NCT02908308 about?
NCT02908308 is a clinical study titled "Targeted Hypothermia Versus Targeted Normothermia After Out-of-hospital Cardiac Arrest". ILCOR guidelines recommend Target Temperature Management (TTM) to between 32°C and 36°C after out-of-hospital cardiac arrest, based on low quality evidence. In a previous trial, TTM at 33°C did not confer a survival benefit or improved neurological function, compared to TTM at 36°C. A lower target t...
What is the current status of trial NCT02908308?
This trial is currently completed. It is a NA study. The enrollment target is 1,900 participants. The study started on 2017-11-18. Estimated completion is 2022-12-31.
What conditions does trial NCT02908308 study?
This clinical trial studies the following conditions: Out-Of-Hospital Cardiac Arrest.
What interventions are being tested in trial NCT02908308?
The interventions under investigation include: Targeted temperature management to 33°C (PROCEDURE), Standard care with early treatment of fever (PROCEDURE).
Who is sponsoring clinical trial NCT02908308?
This trial is sponsored by Helsingborgs Hospital, which has 1 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02908308 being conducted?
This trial has 20 study locations across New York, Pennsylvania, New South Wales, Queensland, Victoria. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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