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RECRUITING Phase 3

Study to evaLuate the effIcacy and Safety of abeLacimab in High-risk Patients With Atrial Fibrillation Who Have Been Deemed Unsuitable for Oral antiCoagulation (LILAC-TIMI 76)

NCT05712200 · View on ClinicalTrials.gov ↗

Study Summary

A study to evaluate the effect of abelacimab relative to placebo on the rate of ischemic stroke or systemic embolism (SE) in patients with Atrial Fibrillation (AF) who have been deemed by their responsible physicians or by their own decision to be unsuitable for oral anticoagulation therapy.

Conditions Studied

Interventions

  • DRUG Placebo
  • BIOLOGICAL Abelacimab

Study Locations (20)

California

  • Anthos Investigative Site 9929 — Huntington Beach
  • Anthos Investigative Site 9959 — Imperial
  • Anthos Investigative Site 9921 — Lancaster
  • Anthos Investigative Site 1078 — Loma Linda
  • Anthos Investigative Site 1077 — Los Angeles
  • Anthos Investigative Site 1015 — Northridge
  • Anthos Investigative Site 1070 — Redding
  • Anthos Investigative Site 1071 — San Dimas
  • Anthos Investigative Site 1076 — Santa Ana
  • Anthos Investigative Site 9938 — Santa Rosa
  • Anthos Investigative Site 9908 — South Gate
  • Anthos Investigative Site 9907 — Vista

Alabama

  • Anthos Investigative Site 1040 — Birmingham
  • Anthos Investigational site 9939 — Birmingham
  • Anthos Investigative Site 9947 — Birmingham
  • Anthos Investigative Site 1041 — Mobile

Arizona

  • Anthos Investigative Site 1089 — Gilbert
  • Anthos Investigative Site 1099 — Peoria
  • Anthos Investigative Site 9906 — Phoenix
  • Anthos Investigative Site 9927 — Yuma

Trial Details

FieldValue
Enrollment Target 1,900 participants
Start Date 2022-12-27
Est. Completion 2026-10-31
Phase Phase 3

Sponsor

Anthos Therapeutics

3 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05712200

The ClinicalTrials.gov registry entry for NCT05712200 describes a study currently listed as recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 1,900 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Anthos Therapeutics, which has 3 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Atrial Fibrillation (AF) appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT05712200 reports 20 study locations spanning 3 distinct geographic areas — top geographies include California, Alabama, Arizona. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT05712200 about?

NCT05712200 is a clinical study titled "Study to evaLuate the effIcacy and Safety of abeLacimab in High-risk Patients With Atrial Fibrillation Who Have Been Deemed Unsuitable for Oral antiCoagulation (LILAC-TIMI 76)". A study to evaluate the effect of abelacimab relative to placebo on the rate of ischemic stroke or systemic embolism (SE) in patients with Atrial Fibrillation (AF) who have been deemed by their responsible physicians or by their own decision to be unsuitable for oral anticoagulation therapy.

What is the current status of trial NCT05712200?

This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 1,900 participants. The study started on 2022-12-27. Estimated completion is 2026-10-31.

What conditions does trial NCT05712200 study?

This clinical trial studies the following conditions: Atrial Fibrillation (AF). These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT05712200?

The interventions under investigation include: Placebo (DRUG), Abelacimab (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT05712200?

This trial is sponsored by Anthos Therapeutics, which has 3 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT05712200 being conducted?

This trial has 20 study locations across Alabama, Arizona, California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial