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NCT02851511 · ClinicalTrials.gov registry record · NA
Augmenting Cognitive Training In Older Adults
A NA study, sponsored by University of Florida.
- Completed
- Registry status
- NA
- Development phase
- 379
- Enrollment target
NCT02851511: Completed NA study, sponsored by University of Florida.
NCT02851511 is a NA study that has completed, run by University of Florida. The registered enrollment target is 379 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (73% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02851511, a NA study, has completed, sponsored by University of Florida.
- COMPLETED
- Registry status
- NA
- Development phase
- 379 participants
- Enrollment target
Study Summary
A two-phase adaptive randomized clinical trial will examine the individual and combined impact of pairing cognitive training with transcranial direct current stimulation (tDCS). tDCS is a method of non-invasive brain stimulation that directly stimulates brain regions involved in active cognitive function and could enhance neural plasticity when paired with a training task. We will compare changes in cognitive and brain function resulting from CT and ET combined with tDCS using a comprehensive neurocognitive, clinical, and multimodal neuroimaging assessment of brain structure, function, and metabolic state. Functional magnetic resonance imaging (FMRI) will be used to assess brain response during working memory, attention, and memory encoding; the active cognitive abilities trained by CT. Proton magnetic resonance spectroscopy (MRS) will assess cerebral metabolites, including GABA concentrations sensitive to neural plasticity. We hypothesize that: 1) tDCS will enhance neurocognitive function, brain function, and functional outcomes from CT, with combined CT and tDCS providing the most benefit; 2) Effects of tDCS on CT will be maintained up to 12 months following training, and 3) Neuroimaging biomarkers of cerebral metabolism, neural plasticity (GABA concentrations) and functional brain response (FMRI) during resting vs. active cognitive tasks will predict individual response to tDCS.
Primary Outcome
Composite measure of cognitive ability as defined by NIH toolbox fluid cognition fully corrected T-score. Minimum change = -13, Maximum change = 26. Higher scores mean a better outcome. The minimum and maximum for Cognitive Training + Active Stimulation, Cognitive Training + Sham Stimulation, Educational Training + Active Stimulation and Educational Training + Sham Stimulation are (-13, 20) and (-10, 26), respectively. This outcome is measured for the participants who received cognitive training
Interventions
- BEHAVIORAL Cognitive Training
- DEVICE tDCS (active stimulation)
- DEVICE tDCS (sham stimulation)
- BEHAVIORAL Educational Training
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 379 participants |
| Start Date | 2017-08-08 |
| Est. Completion | 2022-04-30 |
| Phase | NA |
What the finished NCT02851511 record still lists
NCT02851511 is an interventional study that assigns participants to a tested intervention. The registered 379 participants enrollment target is mid-sized for trials with a published cap, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (73% lower).
The record links to 0 conditions, and to 4 interventions - of which Cognitive Training is the first listed.
NCT02851511 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02851511 about?
NCT02851511 is a clinical study titled "Augmenting Cognitive Training In Older Adults". A two-phase adaptive randomized clinical trial will examine the individual and combined impact of pairing cognitive training with transcranial direct current stimulation (tDCS). tDCS is a method of non-invasive brain stimulation that directly stimulates brain regions involved in active cognitive fun...
What is the current status of trial NCT02851511?
This trial is currently completed. It is a NA study. The enrollment target is 379 participants. The study started on 2017-08-08. Estimated completion is 2022-04-30.
What interventions are being tested in trial NCT02851511?
The interventions under investigation include: Cognitive Training (BEHAVIORAL), tDCS (active stimulation) (DEVICE), tDCS (sham stimulation) (DEVICE), Educational Training (BEHAVIORAL).
Who is sponsoring clinical trial NCT02851511?
This trial is sponsored by University of Florida, which has 1,106 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02851511's enrollment target sits among peer trials
379 274th of 2000 higher than 1,727 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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