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NCT02795013 · ClinicalTrials.gov registry record
Genetic Study of Families With High Frequency of Hodgkin Lymphoma
A clinical trial, sponsored by St. Jude Children's Research Hospital.
- Completed
- Registry status
- 27
- Enrollment target
NCT02795013: Completed study, sponsored by St. Jude Children's Research Hospital.
NCT02795013 is a clinical trial that has completed, run by St. Jude Children's Research Hospital. The registered enrollment target is 27 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02795013 has completed, sponsored by St. Jude Children's Research Hospital.
- COMPLETED
- Registry status
- 27 participants
- Enrollment target
Study Summary
Hodgkin lymphoma (HL) is a relatively rare disorder with known familiar aggregation (i.e. HL in more than one child, or parent and child). Because affected individuals in familial HL are genetically related, the existence of such families has long been considered as evidence in support of a genetic basis of HL susceptibility. However, it is largely unknown which genetic variations are responsible for recurring HL in families. Because the effects of genetic variants are likely to be strong in familial HL, identification of such variations will potentially reveal biological pathways critical to the pathogenesis of HL. PRIMARY OBJECTIVE: * To perform genome-wide sequencing of families with recurring Hodgkin lymphoma cases (affected as well as non-affected family members) to identify potential disease-causing germline genetic variations. SECONDARY OBJECTIVE: * To describe demographic and clinical features of the affected families.
Primary Outcome
Whole exome sequencing of affected and unaffected individuals in these families will be performed. Genetic variants potentially related to HL will be identified on the basis of its co-segregation with HL disease status (e.g., unique variants in individuals affected by HL would be considered as risk variants). Family members without HL (regardless of any other history of malignancy) will be considered as control and be compared against members with HL.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 27 participants |
| Start Date | 2016-08-17 |
| Est. Completion | 2018-02-27 |
What the finished NCT02795013 record still lists
NCT02795013 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 27 participants, a relatively small participant target.
The record links to 0 conditions, and to 0 interventions.
NCT02795013 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02795013 about?
NCT02795013 is a clinical study titled "Genetic Study of Families With High Frequency of Hodgkin Lymphoma". Hodgkin lymphoma (HL) is a relatively rare disorder with known familiar aggregation (i.e. HL in more than one child, or parent and child). Because affected individuals in familial HL are genetically related, the existence of such families has long been considered as evidence in support of a genetic ...
What is the current status of trial NCT02795013?
This trial is currently completed. The enrollment target is 27 participants. The study started on 2016-08-17. Estimated completion is 2018-02-27.
Who is sponsoring clinical trial NCT02795013?
This trial is sponsored by St. Jude Children's Research Hospital, which has 410 total clinical trials registered on ClinicalTrials.gov.
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