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NCT02767323 · ClinicalTrials.gov registry record · NA
Using TMS to Increase Executive Function in Older Adults
A NA study, sponsored by Duke University.
- Completed
- Registry status
- NA
- Development phase
- 184
- Enrollment target
NCT02767323 is a NA study that has completed, run by Duke University. The registered enrollment target is 184 participants.
The verdict
NCT02767323, a NA study, has completed, sponsored by Duke University.
- COMPLETED
- Registry status
- NA
- Development phase
- 184 participants
- Enrollment target
Study Summary
Cognitive decline and dementia have become important public health issues in our time as medical science has increased lifespan and our society becomes progressively older. A great deal of the cognitive decline due to aging can be explained by decline in working memory (WM), a mental function central to cognition in which aging deficits appear almost universally. Attempts to use WM training to increase WM ability in older adults has had some success, but the transfer of performance enhancements caused by this training to other cognitive skills is controversial. Another intervention that shows much promise is noninvasive stimulation of cerebral cortex using transcranial magnetic stimulation (TMS), which has been shown to increase performance in many cognitive tasks. Here, the investigator proposes to use fMRI-guided rTMS to enhance working memory performance. This will be achieved through three Aims. In the first, registered on this record, the investigator will stimulate both old and young healthy adults while they perform the WM task that will engage the frontoparietal network. To define the optimal rTMS target, rTMS will be applied over the dorsolateral prefrontal cortex (DLPFC: Aim 1a); or over the parietal cortex (PC: Aim 1b). These regions are involved not only in the maintenance of items in WM, but also in their manipulation, therefore applying rTMS over these areas should create WM performance enhancements that will be long-lasting. In Aim 1c, a direct within-subject comparison of these 2 targeted sites is performed. In the second and third Aims, older adults will receive active or sham rTMS over the optimal target (defined in Arm 1) during two weeks of daily sessions while they perform the WM tasks. In the second Aim, the investigator hopes to demonstrate that the cumulative effect of multiple TMS sessions, in tandem with the synergistic effects of simultaneous TMS + WM training, create WM performance enhancements greater than those found with WM training
Interventions
- DEVICE Sham rTMS
- DEVICE rTMS
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 184 participants |
| Start Date | 2016-08-15 |
| Est. Completion | 2020-03-16 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT02767323
The ClinicalTrials.gov registry entry for NCT02767323 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 184 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Duke University, which has 1,725 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 2 interventions - of which Sham rTMS is the first listed.
NCT02767323 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT02767323 about?
NCT02767323 is a clinical study titled "Using TMS to Increase Executive Function in Older Adults". Cognitive decline and dementia have become important public health issues in our time as medical science has increased lifespan and our society becomes progressively older. A great deal of the cognitive decline due to aging can be explained by decline in working memory (WM), a mental function centra...
What is the current status of trial NCT02767323?
This trial is currently completed. It is a NA study. The enrollment target is 184 participants. The study started on 2016-08-15. Estimated completion is 2020-03-16.
What interventions are being tested in trial NCT02767323?
The interventions under investigation include: Sham rTMS (DEVICE), rTMS (DEVICE).
Who is sponsoring clinical trial NCT02767323?
This trial is sponsored by Duke University, which has 1,725 total clinical trials registered on ClinicalTrials.gov.
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