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NCT02708394 · ClinicalTrials.gov registry record · Early Phase 1
Molecular Mechanisms of Antipsychotic-induced Insulin Resistance
A Early Phase 1 study, sponsored by Wayne State University.
- Completed
- Registry status
- Early Phase 1
- Development phase
- 31
- Enrollment target
NCT02708394: Completed Early Phase 1 study, sponsored by Wayne State University.
NCT02708394 is a Early Phase 1 study that has completed, run by Wayne State University. The registered enrollment target is 31 participants, below the 53-participant average among 2,764 other Early Phase 1 trials with a reported enrollment target (42% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02708394, a Early Phase 1 study, has completed, sponsored by Wayne State University.
- COMPLETED
- Registry status
- Early Phase 1
- Development phase
- 31 participants
- Enrollment target
Study Summary
This study will investigate the molecular mechanisms of atypical-antipsychotic induced insulin resistance. This will be accomplished by administering olanzapine or placebo to healthy subjects for 7 days and analyzing genetic and protein changes in peripheral tissues known to play an important role in insulin resistance pathophysiology.
Primary Outcome
Change in peripheral tissue candidate gene methylation will be measured in the olanzapine intervention group compared to placebo
Interventions
- DRUG placebo
- DRUG olanzapine
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 31 participants |
| Start Date | 2017-02-01 |
| Est. Completion | 2023-10-01 |
| Phase | Early Phase 1 |
What the finished NCT02708394 record still lists
NCT02708394 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 31 participants, a relatively small participant target, below the 53-participant average among 2,764 other Early Phase 1 trials with a reported enrollment target (42% lower).
The record links to 0 conditions, and to 2 interventions - of which placebo is the first listed.
NCT02708394 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02708394 about?
NCT02708394 is a clinical study titled "Molecular Mechanisms of Antipsychotic-induced Insulin Resistance". This study will investigate the molecular mechanisms of atypical-antipsychotic induced insulin resistance. This will be accomplished by administering olanzapine or placebo to healthy subjects for 7 days and analyzing genetic and protein changes in peripheral tissues known to play an important role i...
What is the current status of trial NCT02708394?
This trial is currently completed. It is a Early Phase 1 study. The enrollment target is 31 participants. The study started on 2017-02-01. Estimated completion is 2023-10-01.
What interventions are being tested in trial NCT02708394?
The interventions under investigation include: placebo (DRUG), olanzapine (DRUG).
Who is sponsoring clinical trial NCT02708394?
This trial is sponsored by Wayne State University, which has 163 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02708394's enrollment target sits among peer trials
31 794th of 2000 higher than 1,195 of 2,000 other Early Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Early Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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