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NCT02703766 · ClinicalTrials.gov registry record · NA
Weight Gain and Adipose Tissue
A NA study, sponsored by Mayo Clinic.
- Completed
- Registry status
- NA
- Development phase
- 14
- Enrollment target
NCT02703766: Completed NA study, sponsored by Mayo Clinic.
NCT02703766 is a NA study that has completed, run by Mayo Clinic. The registered enrollment target is 14 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02703766, a NA study, has completed, sponsored by Mayo Clinic.
- COMPLETED
- Registry status
- NA
- Development phase
- 14 participants
- Enrollment target
Study Summary
This study aims to examine the role of weight gain in adipose tissue immune cell influx and development of obesity related cardiometabolic disorders. Adipose tissue-mediated chronic systemic inflammation is implicated in the development of cardiometabolic disorders in obesity. Therefore, resolution of adipose tissue inflammation may be key to ameliorating obesity-associated dyslipidemia, insulin-resistance, and cardiovascular disease. Proinflammatory cytokines contribute to the initial influx of immune cells into adipose tissue during weight gain. However, mechanisms regulating these cytokines in the adipose tissue milieu and the effects of weight gain on adipose tissue are not completely understood. The study proposes to investigate the molecular events contributing to increased infiltration of macrophages and T-cells into adipose tissue during weight gain. The central hypothesis is that in lean subjects (with low body fat mass), healthy fat gain which is associated with decreased expression of proinflammatory cytokines. However, in obesity (high body fat mass), adipose tissue is altered, which permits increased expression of inflammatory cytokines and further fat gain results in influx of immune cells. To test the hypothesis, adipose tissue from well characterized lean (control, with low body fat) and obese individuals (with high body fat) at baseline and after a modest 5% weight gain will be used. Adipose tissue samples after subsequent weight loss will also be examined. For this study, obesity will be defined by body composition rather than body mass index (BMI), as several studies have shown that BMI does not adequately define obesity and several individuals with normal BMI may indeed have high body fat mass. Individuals with body fat content ≤25% for men, \& \<35% for women) will be considered lean and individuals with body fat content \>25% for men, ≥35% for women will be considered obese.
Interventions
- BEHAVIORAL overfeeding induced weight gain
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 14 participants |
| Start Date | 2016-04 |
| Est. Completion | 2018-12 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT02703766
The ClinicalTrials.gov registry entry for NCT02703766 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 14 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Mayo Clinic, which has 2,844 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which overfeeding induced weight gain is the first listed.
NCT02703766 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT02703766 about?
NCT02703766 is a clinical study titled "Weight Gain and Adipose Tissue". This study aims to examine the role of weight gain in adipose tissue immune cell influx and development of obesity related cardiometabolic disorders. Adipose tissue-mediated chronic systemic inflammation is implicated in the development of cardiometabolic disorders in obesity. Therefore, resolution ...
What is the current status of trial NCT02703766?
This trial is currently completed. It is a NA study. The enrollment target is 14 participants. The study started on 2016-04. Estimated completion is 2018-12.
What interventions are being tested in trial NCT02703766?
The interventions under investigation include: overfeeding induced weight gain (BEHAVIORAL).
Who is sponsoring clinical trial NCT02703766?
This trial is sponsored by Mayo Clinic, which has 2,844 total clinical trials registered on ClinicalTrials.gov.
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