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NCT02425566 · ClinicalTrials.gov registry record · Phase 1
Role of Sympathetic Activity and Splanchnic Capacitance in Hypertension
A Phase 1 study of Hypertension, sponsored by Vanderbilt University.
- Active
- Registry status
- Phase 1
- Development phase
- 12
- Enrollment target
- 1
- Study location
NCT02425566: Active Phase 1 study of Hypertension, sponsored by Vanderbilt University.
NCT02425566 is a Phase 1 study of Hypertension that is active but no longer recruiting, run by Vanderbilt University. The registered enrollment target is 12 participants, below the 3,507-participant average among 470 other Hypertension trials with a reported enrollment target (100% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02425566, a Phase 1 study of Hypertension, is active but no longer recruiting, sponsored by Vanderbilt University.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 1
- Development phase
- 12 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of this study is to better understand the role of the abdominal veins (splanchnic capacitance) and the sympathetic nervous system in human hypertension. The investigators will test the hypothesis that constriction of abdominal veins due to sympathetic activation contributes to human hypertension. Splanchnic capacitance will be assessed in normotensive and hypertensive subjects at baseline and during acute blockade of the autonomic nervous system.
Primary Outcome
The primary outcome will be the splanchnic capacitance, defined as the pressure-venous curve (P-V curve), during trimethaphan infusion adjusted for its baseline values. For analysis, the Y-intercept (volume) and the slope of the P-V relationship during autonomic blockade adjusted by their corresponding baseline values will be compared between groups.
Conditions Studied
Interventions
- DRUG Trimethaphan
- DRUG Nitroglycerin
Study Locations (1)
Tennessee
- Autonomic Dysfunction Center - Nashville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 12 participants |
| Start Date | 2015-04 |
| Est. Completion | 2026-08 |
| Phase | Phase 1 |
What the registry record for NCT02425566 still lists
NCT02425566 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 12 participants, a relatively small participant target, below the 3,507-participant average among 470 other Hypertension trials with a reported enrollment target (100% lower).
The record links to 1 condition, with Hypertension appearing as the primary indexed condition, and to 2 interventions - of which Trimethaphan is the first listed.
NCT02425566 reports a single indexed study location in Tennessee.
Frequently Asked Questions
What is clinical trial NCT02425566 about?
NCT02425566 is a clinical study titled "Role of Sympathetic Activity and Splanchnic Capacitance in Hypertension". The purpose of this study is to better understand the role of the abdominal veins (splanchnic capacitance) and the sympathetic nervous system in human hypertension. The investigators will test the hypothesis that constriction of abdominal veins due to sympathetic activation contributes to human hype...
What is the current status of trial NCT02425566?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 12 participants. The study started on 2015-04. Estimated completion is 2026-08.
What conditions does trial NCT02425566 study?
This clinical trial studies the following conditions: Hypertension.
What interventions are being tested in trial NCT02425566?
The interventions under investigation include: Trimethaphan (DRUG), Nitroglycerin (DRUG).
Who is sponsoring clinical trial NCT02425566?
This trial is sponsored by Vanderbilt University, which has 430 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02425566 being conducted?
This trial has 1 study location across Tennessee. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Hypertension
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT02425566's enrollment target sits among peer trials
12 457th of 470 higher than 10 of 470 other Hypertension trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Hypertension trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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