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COMPLETED Phase 1

A Study to Assess the Safety and Pharmacokinetics of MOXR0916 and Atezolizumab (Also Known as MPDL3280A or Anti-PD-L1) in Participants With Locally Advanced or Metastatic Solid Tumors

NCT02410512 · View on ClinicalTrials.gov ↗

Study Summary

This Phase Ib, open-label, dose-escalation study will evaluate the safety, tolerability, and pharmacokinetics of the combination of MOXR0916 and atezolizumab in participants with locally advanced, recurrent, or metastatic incurable solid malignancy that has progressed after available standard therapy; or for which standard therapy has proven to be ineffective or intolerable or is considered inappropriate; or for which a clinical trial of an investigational agent is a recognized standard of care. Participants will be enrolled in two stages: a dose-escalation stage and an expansion stage.

Conditions Studied

Interventions

  • DRUG Atezolizumab (MPDL3280A), an engineered anti-programmed death-ligand 1 [PD-L1] antibody
  • DRUG MOXR0916, a humanized agonist anti-OX40 monoclonal antibody

Study Locations (20)

Other

  • Institut Jules Bordet — Anderlecht
  • UZ Gent — Ghent
  • Sint Augustinus Wilrijk — Wilrijk
  • Gustave Roussy — Villejuif

Massachusetts

  • Beth Israel Deaconess Medical Center — Boston
  • Dana Farber Can Ins — Boston

Victoria

  • Austin Hospital — Heidelberg
  • Peter Maccallum Cancer Centre — Melbourne

Arizona

  • HonorHealth Research Institute - Bisgrove — Scottsdale

Colorado

  • University of Colorado — Aurora

Connecticut

  • Yale School of Medicine — New Haven

District of Columbia

  • Georgetown University Medical Center Lombardi Cancer Center — Washington D.C.

Illinois

  • University Of Chicago Medical Center; Section Of Hematology/Oncology — Chicago

Trial Details

FieldValue
Enrollment Target 610 participants
Start Date 2015-04-24
Est. Completion 2019-11-22
Phase Phase 1

Sponsor

Genentech

206 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT02410512

The ClinicalTrials.gov registry entry for NCT02410512 describes a study currently listed as completed. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 610 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Genentech, which has 206 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Neoplasms appearing as the primary indexed condition, and to 2 interventions — of which Atezolizumab (MPDL3280A), an engineered anti-programmed death-ligand 1 [PD-L1] antibody is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT02410512 reports 20 study locations spanning 15 distinct geographic areas — top geographies include Other, Massachusetts, Victoria. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT02410512 about?

NCT02410512 is a clinical study titled "A Study to Assess the Safety and Pharmacokinetics of MOXR0916 and Atezolizumab (Also Known as MPDL3280A or Anti-PD-L1) in Participants With Locally Advanced or Metastatic Solid Tumors". This Phase Ib, open-label, dose-escalation study will evaluate the safety, tolerability, and pharmacokinetics of the combination of MOXR0916 and atezolizumab in participants with locally advanced, recurrent, or metastatic incurable solid malignancy that has progressed after available standard therap...

What is the current status of trial NCT02410512?

This trial is currently completed. It is a Phase 1 study. The enrollment target is 610 participants. The study started on 2015-04-24. Estimated completion is 2019-11-22.

What conditions does trial NCT02410512 study?

This clinical trial studies the following conditions: Neoplasms. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT02410512?

The interventions under investigation include: Atezolizumab (MPDL3280A), an engineered anti-programmed death-ligand 1 [PD-L1] antibody (DRUG), MOXR0916, a humanized agonist anti-OX40 monoclonal antibody (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT02410512?

This trial is sponsored by Genentech, which has 206 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT02410512 being conducted?

This trial has 20 study locations across Arizona, Colorado, Connecticut, District of Columbia, Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial